{"created":"2023-05-15T14:58:43.693420+00:00","id":79673,"links":{},"metadata":{"_buckets":{"deposit":"46936105-0191-42c5-92a4-d577fc67b276"},"_deposit":{"created_by":1,"id":"79673","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"79673"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00079673","sets":["1"]},"author_link":["898237","898261","898249","898244","898254","898253","898273","898259","898242","898233","898271","898252","898260","898234","898232","898236","898269","898262","898250","898268","898266","898279","898241","898231","898270","898275","898256","898255","898239","898247","898240","898243","898280","898277","898278","898258","898246","898264","898257","898274","898230","898235","898251","898263","898267","898276","898245","898272","898265","898238","898248"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1167","bibliographicPageStart":"1157","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Nature Neuroscience"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The chemogenetic technology Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) affords remotely reversible control of cellular signaling, neuronal activity and behavior. Although the combination of muscarinic-based DREADDs with clozapine-N-oxide (CNO) has been widely used, sluggish kinetics, metabolic liabilities, and potential off-target effects of CNO represent areas for improvement. Here we provide a new high affinity and selective agonist deschloroclozapine (DCZ) for muscarinic-based DREADDs. Positron emission tomography revealed that DCZ selectively bound to and occupied DREADDs in both mice and monkeys. Systemic delivery of low doses of DCZ (1 or 3 μg/kg) enhanced neuronal activity via hM3Dq within minutes in mice and monkeys. Intramuscular injections of DCZ (100 μg/kg) reversibly induced spatial working memory deficits in monkeys expressing hM4Di in the prefrontal cortex. DCZ represents the most potent, selective, metabolically stable and fast-acting DREADD agonist reported with utility in both mice and non-human primates for a variety of applications.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"32632286","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41593-020-0661-3","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41593-020-0661-3","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1097-6256","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nagai, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"898230","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyakawa, Naohisa"}],"nameIdentifiers":[{"nameIdentifier":"898231","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takuwa, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"898232","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hori, Yukiko"}],"nameIdentifiers":[{"nameIdentifier":"898233","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oyama, Kei"}],"nameIdentifiers":[{"nameIdentifier":"898234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ji, Bin"}],"nameIdentifiers":[{"nameIdentifier":"898235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Manami, Takahashi"}],"nameIdentifiers":[{"nameIdentifier":"898236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xi-Ping, Huang"}],"nameIdentifiers":[{"nameIdentifier":"898237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"T. Slocum, Samuel"}],"nameIdentifiers":[{"nameIdentifier":"898238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"F. DiBerto, Jeffrey"}],"nameIdentifiers":[{"nameIdentifier":"898239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xiong, Yan"}],"nameIdentifiers":[{"nameIdentifier":"898240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Urushihata, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"898241","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirabayashi, Toshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"898242","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimoto, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"898243","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mimura, Koki"}],"nameIdentifiers":[{"nameIdentifier":"898244","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"G. 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