{"created":"2023-05-15T14:58:39.756442+00:00","id":79586,"links":{},"metadata":{"_buckets":{"deposit":"e27112da-088e-410a-9698-a2431772f0fb"},"_deposit":{"created_by":1,"id":"79586","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"79586"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00079586","sets":["10:29"]},"author_link":["857926","857921","857932","857927","857925","857933","857931","857920","857929","857930","857922","857928","857923","857924"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-02-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[64Cu]Cu-ATSMは脳腫瘍への治療効果が期待される放射性薬剤である。我々は無菌アイソレーターを用いて臨床用[64Cu]Cu-ATSM注射液を製造したので報告する。【方法】無菌アイソレーター内で過酸化水素ガス滅菌を行い、グレードA環境下でライン組み付けとリークチェックを行った。次に、原料のATSM/DMSO溶液を導入し、製造した64Cuグリシン溶液と混合し、さらにアスコルビン酸水溶液を加えてよく撹拌し[64Cu]Cu-ATSM注射液を合成した。【結果】[64Cu]Cu-ATSM注射液は3.0～3.7GBqの収量であり、64Cu製造後17～25分で合成し、回収率は約85％であった。作業者の被ばく量は30μSv程度であった。【結論】治験薬GMPに準拠した高品位の[64Cu]Cu-ATSM注射液を安定的に製造し、週1回4週連続の臨床提供を可能にした。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第１回千葉地区 技術と支援の活動報告会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"武井, 誠"}],"nameIdentifiers":[{"nameIdentifier":"857920","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 寿"}],"nameIdentifiers":[{"nameIdentifier":"857921","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"深田, 正美"}],"nameIdentifiers":[{"nameIdentifier":"857922","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大矢, 智幸"}],"nameIdentifiers":[{"nameIdentifier":"857923","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本, 裕輝"}],"nameIdentifiers":[{"nameIdentifier":"857924","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村, 和紀"}],"nameIdentifiers":[{"nameIdentifier":"857925","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"857926","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takei, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"857927","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Hisashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"857928","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukada, Masami","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"857929","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohya, Tomoyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"857930","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashimoto, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"857931","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"857932","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"857933","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"無菌アイソレーターを用いた治験薬GMP準拠がん治療薬[64Cu]Cu-ATSM注射液製造","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"無菌アイソレーターを用いた治験薬GMP準拠がん治療薬[64Cu]Cu-ATSM注射液製造"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-19"},"publish_date":"2020-03-19","publish_status":"0","recid":"79586","relation_version_is_last":true,"title":["無菌アイソレーターを用いた治験薬GMP準拠がん治療薬[64Cu]Cu-ATSM注射液製造"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:16:20.785630+00:00"}