@article{oai:repo.qst.go.jp:00079232, author = {Hayashi, Taketsugu and Akikawa, Ryota and Kawasaki, Keisuke and Egawa, Jun and Minamimoto, Takafumi and Kobayashi, Kazuto and Kato, Shigeki and Hori, Yukiko and Nagai, Yuji and Iijima, Atsuhiko and Someya, Toshiyuki and Hasegawa, Isao and Minamimoto, Takafumi and Hori, Yukiko and Nagai, Yuji}, issue = {13}, journal = {Cell Reports}, month = {Mar}, note = {The ability to infer others’ mental states is essential to social interactions. This ability, critically evaluated by testing whether one attributes false beliefs (FBs) to others, has been considered to be uniquely hominid and accompany activation of a distributed brain network. We challenge the taxon-specificity of this ability and identify the causal brain locus by introducing an anticipatory looking FB paradigm combined with chemogenetic neuronal manipulation in macaque monkeys. We find spontaneous gaze bias of macaques implicitly anticipating others’ FB-driven actions. Silencing of the medial prefrontal neuronal activity with inhibitory DREADDs specifically eliminate the implicit gaze bias while leaving the animals’ visually-guided and memory-guided tracking abilities intact. Thus, neuronal activity in the medial prefrontal cortex could have a causal role in FB attribution-like behaviors in the primate lineage, emphasizing the importance of probing the neuronal mechanisms underlying theory-of-mind with relevant macaque animal models.}, pages = {4433--4444}, title = {Macaques exhibit implicit gaze bias anticipating others’ false belief-driven actions via the medial prefrontal cortex}, volume = {30}, year = {2020} }