{"created":"2023-05-15T14:58:23.613496+00:00","id":79222,"links":{},"metadata":{"_buckets":{"deposit":"11ef2315-d17b-4ec5-86d3-f059a583f866"},"_deposit":{"created_by":1,"id":"79222","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"79222"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00079222","sets":["10:28"]},"author_link":["858611","858619","858610","858616","858612","858615","858613","858618","858617","858614"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-11-25","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"低分子Gd錯体型のMRI造影剤は、主に血液脳脊髄関門を通過して脳に到達し、直鎖状配位子を有する一部の化合物が脳に沈着することが報告されている。本研究では、放射線により粒径が1-20 nmの領域で適切に制御されたゼラチンナノゲルを作製し、Gd錯体を担持することで、脳内に侵入せず腎排泄が可能な新規MRI造影剤の開発を行った。さらに、Gdを担持したゼラチンナノゲルのMRI緩和能を評価した上で、マウスを利用したin vivo試験を行い、Gd担持ゼラチンナノゲルの造影効果および腎排泄性と脳内残留性を評価した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第41回日本バイオマテリアル学会大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木村, 敦"}],"nameIdentifiers":[{"nameIdentifier":"858610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 紅"}],"nameIdentifiers":[{"nameIdentifier":"858611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 郁也"}],"nameIdentifiers":[{"nameIdentifier":"858612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木, 伊知男"}],"nameIdentifiers":[{"nameIdentifier":"858613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田口, 光正"}],"nameIdentifiers":[{"nameIdentifier":"858614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"858615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Hong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"858616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Fumiya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"858617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"858618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taguchi, Mitsumasa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"858619","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"脳に移行せず腎排泄が可能な高安全性MRI造影剤への応用を目指した量子ビーム架橋ゼラチンナノゲルの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳に移行せず腎排泄が可能な高安全性MRI造影剤への応用を目指した量子ビーム架橋ゼラチンナノゲルの開発"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-06"},"publish_date":"2020-03-06","publish_status":"0","recid":"79222","relation_version_is_last":true,"title":["脳に移行せず腎排泄が可能な高安全性MRI造影剤への応用を目指した量子ビーム架橋ゼラチンナノゲルの開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:15:01.053850+00:00"}