@article{oai:repo.qst.go.jp:00079024,
 author = {Chio, Okuyama, and Higashi, Tatsuya and Koichi, Ishizu, and Ryusuke, Nakamoto, and Masaaki, Takahashi, and Kuninori, Kusano, and Shinya, Kagawa, and Hiroshi, Yamauchi, and Tatsuya, Higashi},
 issue = {10},
 journal = {Clinical Nuclear Medicine},
 month = {Oct},
 note = {Purpose of the Report 
False-positive bone lesions mimicking bone metastases (bone pseudometastasis) on 18F-FDG PET/CT have often been reported in patients with esophageal cancer. We aimed to evaluate the prevalence and features of these lesions in Japanese patients with esophageal cancer.
Methods 
In this retrospective study, we analyzed 83 FDG PET/CT studies for initial staging of esophageal cancer, and extracted patients with 1 or more localized high uptake sites with no subsequent progression, which were therefore judged to be bone pseudometastasis. The FDG PET/CT imaging features of the bone pseudometastasis were evaluated, and other available imaging and clinical features reviewed.
Results 
Of the 83 patients, 7 had bone pseudometastasis. All 7 were males diagnosed with squamous cell cancer, of which 5 had T1a tumors. Bone pseudometastasis showed normal or ill-defined hyperdense (nonosteolytic) sites compared with the surrounding area on the CT. Additionally, accumulation in the upper vertebral levels of each case was contiguously high compared with the lumbar spines (we named this finding “contiguous accumulation”). On MRI, these findings were visualized as low signals on T1-weighted imaging (T1WI) and T2WI images but were unclear on fat-suppressed T2WI images.
Conclusions 
Among all PET/CT performed for staging of esophageal cancer, 8.3% demonstrated bone pseudometastasis characterized by heterogeneous distribution with severe fatty degeneration of bone marrow accompanied by contiguous accumulation. Caution is required during diagnoses of bone lesions in esophageal cancer patients in Japan to prevent inappropriate therapeutic choices.},
 pages = {771--776},
 title = {Bone Pseudometastasis on 18F-FDG PET in Japanese Patients With Esophageal Cancer},
 volume = {44},
 year = {2019}
}