@article{oai:repo.qst.go.jp:00078475,
 author = {Matsumoto, Atsushi and Sugiyama, Masaaki and Li, Zhenhai and Martel, Anne and Porcar, Lionel and Inoue, Rintaro and Kato, Daiki and Osakabe, Akihisa and Kurumizaka, Hitoshi and Kono, Hidetoshi and Matsumoto, Atsushi and Li, Zhenhai and Kono, Hidetoshi},
 issue = {9},
 journal = {Biophysical journal},
 month = {Jan},
 note = {An overlapping dinucleosome (OLDN) is a structure composed of one hexasome and one octasome and appears to be formed through nucleosome collision promoted by nucleosome remodeling factor(s). In the present study, the solution structure of the OLDN was investigated through integration of small-angle X-ray and neutron scattering (SAXS and SANS, respectively), computer modeling, and molecular dynamics simulations. Starting from the crystal structure, we generated a conformational ensemble based on normal mode analysis, and searched for the conformations that well reproduced the SAXS and SANS scattering curves. We found that inclusion of histone tails, which are not observed in the crystal structure, greatly improved model quality. The obtained structural models suggest that OLDNs adopt a variety of conformations stabilized by histone tails situated at the interface between the hexasome and octasome, simultaneously binding to both the hexasomal and octasomal DNA. In addition, our models define a possible direction for the conformational changes or dynamics, which may provide important information that furthers our understanding of the role of chromatin dynamics in gene regulation.},
 pages = {2209--2219},
 title = {Structural Studies of Overlapping Dinucleosomes in Solution},
 volume = {118},
 year = {2020}
}