{"created":"2023-05-15T14:57:38.621917+00:00","id":78233,"links":{},"metadata":{"_buckets":{"deposit":"7655abf0-9a84-4a97-ae24-ebd8f5938d56"},"_deposit":{"created_by":1,"id":"78233","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"78233"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00078233","sets":["1"]},"author_link":["998318","998328","998320","998334","998327","998325","998323","998329","998331","998321","998332","998330","998336","998337","998324","998322","998333","998326","998335","998319"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"116478","bibliographicVolumeNumber":"209","bibliographic_titles":[{"bibliographic_title":"NeuroImage"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Early-maturing girls are relatively likely to experience compromised psychobehavioral outcomes. Some studies have explored the association between puberty and brain morphology in adolescents, while the results were non-specific for females or the method was a region-of-interest analysis. To our knowledge, no large-scale study has comprehensively explored the effects of pubertal timing on whole-brain volumetric development or the neuroanatomical substrates of the association in girls between pubertal timing and psychobehavioral outcomes. We collected structural magnetic resonance imaging (MRI) data of a subsample (N ​= ​203, mean age 11.6 years) from a large-scale population-based birth cohort. Tanner stage, a scale of physical maturation in adolescents, was rated almost simultaneously with MRI scan. The Strengths and Difficulties Questionnaire total difficulties (SDQ-TD) scores were rated by primary parents some duration after MRI scan (mean age 12.1 years). In each sex group, we examined brain regions associated with Tanner stage using whole-brain analysis controlling for chronological age, followed by an exploration of brain regions also associated with the SDQ-TD scores. We also performed mediation analyses. In girls, Tanner stage was significantly negatively correlated with gray matter volumes (GMVs) in the anterior/middle cingulate cortex (ACC/MCC), of which the subgenual ACC (sgACC) showed a negative correlation between GMVs and SDQ-TD scores. Smaller GMVs in the sgACC mediated the association between higher Tanner stages and higher SDQ-TD scores. We found no significant results in boys. Our results from a minimally biased, large-scale sample provide new insights into neuroanatomical correlates of the effect of pubertal timing on developmental psychological difficulties emerging in adolescence.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31884058","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.neuroimage.2019.116478","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S1053811919310699?via%3Dihub","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1053-8119","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okada, Naohiro"}],"nameIdentifiers":[{"nameIdentifier":"998318","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yahata, Noriaki"}],"nameIdentifiers":[{"nameIdentifier":"998319","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koshiyama, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"998320","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morita, Kentaro"}],"nameIdentifiers":[{"nameIdentifier":"998321","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sawada, Kingo"}],"nameIdentifiers":[{"nameIdentifier":"998322","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanata, Sho"}],"nameIdentifiers":[{"nameIdentifier":"998323","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujikawa, Shinya"}],"nameIdentifiers":[{"nameIdentifier":"998324","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugimoto, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"998325","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toriyama, Rie"}],"nameIdentifiers":[{"nameIdentifier":"998326","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masaoka, Mio"}],"nameIdentifiers":[{"nameIdentifier":"998327","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koike, Shinsuke"}],"nameIdentifiers":[{"nameIdentifier":"998328","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Araki, Tsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"998329","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kano, Yukiko"}],"nameIdentifiers":[{"nameIdentifier":"998330","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"998331","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Syudo"}],"nameIdentifiers":[{"nameIdentifier":"998332","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Shuntaro"}],"nameIdentifiers":[{"nameIdentifier":"998333","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishida, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"998334","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mariko, Hiraiwa-Hasegawa"}],"nameIdentifiers":[{"nameIdentifier":"998335","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kasai, Kiyoto"}],"nameIdentifiers":[{"nameIdentifier":"998336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noriaki, Yahata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"998337","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Smaller anterior subgenual cingulate volume mediates the effect of girls’ early sexual maturation on negative psychobehavioral outcome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Smaller anterior subgenual cingulate volume mediates the effect of girls’ early sexual maturation on negative psychobehavioral outcome"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-12-25"},"publish_date":"2019-12-25","publish_status":"0","recid":"78233","relation_version_is_last":true,"title":["Smaller anterior subgenual cingulate volume mediates the effect of girls’ early sexual maturation on negative psychobehavioral outcome"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:49:24.070913+00:00"}