{"created":"2023-05-15T14:57:36.489010+00:00","id":78185,"links":{},"metadata":{"_buckets":{"deposit":"1381a3bc-bf0f-46fc-95d0-9655b2e89b0e"},"_deposit":{"created_by":1,"id":"78185","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"78185"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00078185","sets":["10:29"]},"author_link":["816997","816998"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-08-23","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PETと薬はとても相性の良い組み合わせである。11Cがポジトロン核種なので、治療薬そのものを標識できる場合も多い。標識した薬を投与してPETで撮れば、その薬がどのように体内に分布し集積するか、PET画像そのもので見える。では、その薬はどの程度組織内に移行するのだろう、というシンプルな問いに「定量的」に応えようとするのがPET動態解析の入り口ならば、受容体やアミロイドβリガンドなど、生体内ターゲット分子に結合し、動態解析でその濃度を定量するのは一歩奥の世界と言える。中枢神経系をターゲット薬剤開発でのPETを使った研究では、その入口に立ったり奥座敷を覗き込んだりの双方のアプローチを状況に応じて使っていく。そのような場面での「PET動態解析」の役割の一端を紹介したい。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"PETサマーセミナー2019 in 福島夜の学校「理工学基礎」で講演(謝金なし)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"816997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Chie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"816998","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"PET動態解析と創薬への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PET動態解析と創薬への応用"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-12-23"},"publish_date":"2019-12-23","publish_status":"0","recid":"78185","relation_version_is_last":true,"title":["PET動態解析と創薬への応用"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:24:51.012356+00:00"}