{"created":"2023-05-15T14:57:35.647034+00:00","id":78165,"links":{},"metadata":{"_buckets":{"deposit":"4cdde014-2874-4fcd-b08e-ff8fee7c058f"},"_deposit":{"created_by":1,"id":"78165","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"78165"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00078165","sets":["1"]},"author_link":["997105","997108","997104","997106","997107"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"178","bibliographicPageStart":"172","bibliographicVolumeNumber":"96","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Accumulated damage in neural stem cells (NSCs) during brain tumor radiotherapy causes cognitive dysfunction to the patients. Carbon-ion radiotherapy can reduce undesired irradiation of normal tissues more efficiently than conventional photon radiotherapy. This study elucidates the responses of NSCs to carbon-ion radiation. Methods: Human NSCs and glioblastoma A-172 cells were irradiated with carbon-ion radiation and gamma-rays, which have different linear-energy-transfer (LET) values of 108 and 0.2 keV/μm, respectively. After irradiation, growth rates were measured, apoptotic cells were detected by flow cytometry, and DNA synthesizing cells were immunocytochemically visualized. Results: Growth rates of NSCs and A-172 cells were decreased after irradiation. The percentages of apoptotic cells were remarkably increased in NSCs but not in A-172 cells. In contrast, the fractions of DNA synthesizing A-172 cells were decreased in a dose-dependent manner. These results indicate that apoptosis induction and DNA synthesis inhibition contribute to the growth inhibition of NSCs and glioblastoma cells, respectively. In addition, high-LET carbon ions induced more profound effects than low-LET gamma-rays. Conclusions: Apoptosis is an important clinical target to protect NSCs during brain tumor radiotherapy using carbon-ion radiation as well as conventional X-rays.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1080/09553002.2020.1683639","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.tandfonline.com/doi/full/10.1080/09553002.2020.1683639","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0955-3002","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yokota, Yuuichiro"}],"nameIdentifiers":[{"nameIdentifier":"997104","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wada, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"997105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Funayama, Tomo"}],"nameIdentifiers":[{"nameIdentifier":"997106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuuichiro, Yokota","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"997107","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomo, Funayama","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"997108","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Distinct modes of death in human neural stem and glioblastoma cells irradiated with carbon-ion radiation and gamma-rays","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Distinct modes of death in human neural stem and glioblastoma cells irradiated with carbon-ion radiation and gamma-rays"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-18"},"publish_date":"2019-09-18","publish_status":"0","recid":"78165","relation_version_is_last":true,"title":["Distinct modes of death in human neural stem and glioblastoma cells irradiated with carbon-ion radiation and gamma-rays"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:54:41.625560+00:00"}