@misc{oai:repo.qst.go.jp:00078112,
 author = {Kang, Hangyu and Nishikido, Fumihiko and Takyu, Sodai and Mohammadi, Akram and Toramatsu, Chie and Yamamoto, Seiichi and Horita, Ryo and Yamaya, Taiga and Kang, Hangyu and Nishikido, Fumihiko and Takyu, Sodai and Mohammadi, Akram and Toramatsu, Chie and Yamaya, Taiga},
 month = {Apr},
 note = {[Purpose]
Heavy ion therapy has been used as a promising cancer therapy technique due to its Bragg peak characteristics. Recently, the potential of radioactive ion beam therapy has been investigated with a combination of the OpenPET system to improve the accuracy of in vivo beam range verification. The aim of this study is to estimate the O-15 beam range in an acrylic phantom by using luminescence- and Cerenkov-light for beam quality control. 
[Methods]
In this study, an acrylic phantom (10 × 10 × 10 cm3) was irradiated by O-15 beam for 8 min. The energy, lateral beam size (FWHM), and total number of the O-15 ion beam were 250 MeV/n, 19.8 mm, and 2.4×1010, respectively. In order to obtain the luminescence image and Cerenkov image, an optical system which consisted of lens and a cooled CCD camera (Bitran, BS-40L, Japan) was used. The distance between the surface of the acrylic phantom and the optical lens was set to 52 cm. The luminescence image and Cerenkov image were obtained for 2 min with in-beam and offline-beam condition, respectively The CCD image was acquired with various PMMA range shifter thicknesses (0, 10, 25, 30, 35, 40 mm) to evaluate the range estimation accuracy of the luminescence and Cerenkov imaging. 
[Results]
The stopping position of O-15 ion and the lateral FWHM of the O-15 beam could be visualized using Cerenkov and luminescence imaging, respectively. The Bragg peak shift caused by the PMMA range shifter could be estimated by using Cerenkov and luminescence imaging with accuracies of 0.33 mm, and 0.45 mm, respectively. However, the line profile peak of the Cerenkov image was 2.8 ± 0.5 mm deeper than that of the luminescence image. 
[Conclusion]
In conclusion, the optical imaging could be used for high resolution beam profile monitoring. In the future, in-beam PET and systematic dose profile measurement will be performed to investigate the practical method of beam quality control using the optical imaging technique., 第117回日本医学物理学会学術大会},
 title = {Optical imaging for the range estimation of O-15 beam},
 year = {2019}
}