{"created":"2023-05-15T14:57:20.881198+00:00","id":77824,"links":{},"metadata":{"_buckets":{"deposit":"5c5b740d-50b3-4945-bb0b-30017e998bec"},"_deposit":{"created_by":1,"id":"77824","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"77824"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00077824","sets":["11"]},"author_link":["810278","810279"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"57","bibliographicPageStart":"53","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"日本原子力学会誌　ATOMOΣ"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"個別化医療に直結する｢theranostics(診断と治療の一体化)｣なプローブの開発により，核医 学分野では，診断用 PET/SPECT 核種による診断と核種の付け替え(治療用核種への置換)に よる治療，すなわち標的アイソトープ治療(Targeted Radioisotope Therapy/ TRT)の新時代を 迎えている。近年  線製剤としてラジウム 223 が前立腺癌領域で初めて臨床応用され，従来の  核種を凌駕する治療効果を示している。 線製剤の高い治療効果(高 LET, 高 RBE)と安全性 は幅広い注目を浴びており，次なる  線核種としてアクチニウム 225 やアスタチン 211 の医学 利用も期待されている。現時点で  線 TRT の臨床応用は少ないが，国内でも複数の TRT 臨 床治験が始まり，臨床応用が期待されている。最新の TRT 研究開発の現状を概説する。","subitem_description_type":"Abstract"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"東, 達也"}],"nameIdentifiers":[{"nameIdentifier":"810278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Tatsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"810279","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"標的アイソトープ治療の研究開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"標的アイソトープ治療の研究開発"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-12-06"},"publish_date":"2019-12-06","publish_status":"0","recid":"77824","relation_version_is_last":true,"title":["標的アイソトープ治療の研究開発"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:34:58.551236+00:00"}