{"created":"2023-05-15T14:57:16.083528+00:00","id":77713,"links":{},"metadata":{"_buckets":{"deposit":"f21ec694-2b50-427a-877a-59bf7addea35"},"_deposit":{"created_by":1,"id":"77713","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"77713"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00077713","sets":["1"]},"author_link":["999941","999947","999951","999940","999948","999949","999950","999946","999952","999943","999944","999945","999939","999942","999953"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"324","bibliographicPageStart":"317","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Drug Metabolism and Pharmacokinetics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Quantitative evaluations of the functions of uptake and efflux transporters directly in vivo is desired to understand an efficient hepatobiliary transport of substrate drugs. Pitavastatin is a substrate of organic anion transporting polypeptides (OATPs) and canalicular efflux transporters; thus, it can be a suitable probe for positron-emission tomography (PET) imaging of hepatic transporter functions. To characterize the performance of [18F]PTV-F1, an analogue of pitavastatin, we investigated the impact of rifampicin (a typical OATP inhibitor) coadministration or Bcrp (breast cancer resistance protein) knockout on [18F]PTV-F1 hepatic uptake and efflux in rats by PET imaging. After intravenous administration, [18F]PTV-F1 selectively accumulated in the liver, and the radioactivity detected in plasma, liver, and bile mainly derived from the parent PTV-F1 during the PET study (∼40 min). Coadministration of rifampicin largely decreased the hepatic uptake of [18F]PTV-F1 by 73%. Because of its lower clearance in rats, [18F]PTV-F1 is more sensitive for monitoring changes in hepatic OATP1B function that other previously reported OATP1B PET probes. Rifampicin coadministration also significantly decreased the biliary excretion of radioactivity by 65%. Bcrp knockout did not show a significant impact on its biliary excretion.[18F]PTV-F1 enables quantitative analysis of the hepatobiliary transport system for organic anions.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.dmpk.2019.05.006","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/abs/pii/S1347436719300333#!","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-4367","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kimura, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"999939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yagi, Yusuke"}],"nameIdentifiers":[{"nameIdentifier":"999940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mikamo, Mutsumi"}],"nameIdentifiers":[{"nameIdentifier":"999941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Kazuya"}],"nameIdentifiers":[{"nameIdentifier":"999942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kagawa, Shinya"}],"nameIdentifiers":[{"nameIdentifier":"999943","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arimitsu, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"999944","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"999945","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishii, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"999946","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"999947","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamoto, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"999948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Togashi, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"999949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kusuhara, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"999950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saji, Hideo"}],"nameIdentifiers":[{"nameIdentifier":"999951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatsuya, Higashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryuichi, Nishii","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999953","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evaluation of transporter-mediated hepatobiliary transport of newly developed 18F-labeled pitavastatin derivative, PTV-F1, in rats by PET imaging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of transporter-mediated hepatobiliary transport of newly developed 18F-labeled pitavastatin derivative, PTV-F1, in rats by PET imaging"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-28"},"publish_date":"2019-11-28","publish_status":"0","recid":"77713","relation_version_is_last":true,"title":["Evaluation of transporter-mediated hepatobiliary transport of newly developed 18F-labeled pitavastatin derivative, PTV-F1, in rats by PET imaging"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:43:09.878107+00:00"}