{"created":"2023-05-15T14:57:15.022949+00:00","id":77687,"links":{},"metadata":{"_buckets":{"deposit":"414660e1-6c20-4aa6-8a93-f07c767f7d11"},"_deposit":{"created_by":1,"id":"77687","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"77687"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00077687","sets":["1"]},"author_link":["1002013","1002009","1002010","1002008","1002011","1002007","1002012","1002014"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"3755","bibliographicPageStart":"3745","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Anticancer Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: \nThe study is directed to the effect of resveratrol on the redox-status and viability of leukemic and normal lymphocytes, as well as its ability to sensitize leukemic lymphocytes to anticancer drugs. \nMaterials and Methods: \nCytotoxicity was analyzed by trypan blue staining, apoptosis – by Annexin V test, and oxidative stress – by the intracellular levels of reactive oxygen species (ROS) and protein-carbonyl products. \nResults: \nIncubation of resveratrol in combination with the majority of anticancer drugs resulted in higher toxicity than resveratrol or drug alone. In the case of leukemic lymphocytes treated with barasertib and everolimus in the presence of resveratrol, synergistic cytotoxicity was accompanied by strong induction of apoptosis, increased levels of hydroperoxides and insignificant changes in protein-carbonyl products. None of these parameters changed in normal lymphocytes. \nConclusion: \nResveratrol is a promising supplementary compound for anticancer therapy, that may allow reduction of the therapeutic doses of barasertib and everolimus, minimizing their side-effects.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.21873/anticanres.13523","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ar.iiarjournals.org/content/39/7/3745.abstract","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0250-7005","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IVANOVA, DONIKA"}],"nameIdentifiers":[{"nameIdentifier":"1002007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ZHELEV, ZHIVKO"}],"nameIdentifiers":[{"nameIdentifier":"1002008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Semkova, Severina"}],"nameIdentifiers":[{"nameIdentifier":"1002009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"AOKI, ICHIO"}],"nameIdentifiers":[{"nameIdentifier":"1002010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova, Rumiana"}],"nameIdentifiers":[{"nameIdentifier":"1002011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Semkova, Severina","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1002012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichio, Aoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1002013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova, Rumiana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1002014","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Resveratrol Modulates the Redox-status and Cytotoxicity of Anticancer Drugs by Sensitizing Leukemic Lymphocytes and Protecting Normal Lymphocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Resveratrol Modulates the Redox-status and Cytotoxicity of Anticancer Drugs by Sensitizing Leukemic Lymphocytes and Protecting Normal Lymphocytes"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-28"},"publish_date":"2019-11-28","publish_status":"0","recid":"77687","relation_version_is_last":true,"title":["Resveratrol Modulates the Redox-status and Cytotoxicity of Anticancer Drugs by Sensitizing Leukemic Lymphocytes and Protecting Normal Lymphocytes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:35:37.692057+00:00"}