@misc{oai:repo.qst.go.jp:00077488,
 author = {Wang, Bing and Liu, Cuihua and Tanaka, Kaoru and Katsube, Takanori and Hirakawa, Hirokazu and Ninomiya, Yasuharu and Maruyama, Kouichi and Murakami, Masahiro and Fujita, Kazuko and Liu, Qiang and Fujimori, Akira and Nenoi, Mitsuru and Wang, Bing and Liu, Cuihua and Tanaka, Kaoru and Katsube, Takanori and Hirakawa, Hirokazu and Ninomiya, Yasuharu and Maruyama, Kouichi and Murakami, Masahiro and Fujita, Kazuko and Fujimori, Akira and Nenoi, Mitsuru},
 month = {Nov},
 note = {Radioadaptive response (RAR) was demonstrated in varied biosystems. In mice, the first model called “Yonezawa Effect” was established by Yonezawa and colleagues using X-rays as both the priming and the challenge doses, and rescue of bone marrow death as the endpoint. RAR is capable of reducing genotoxicity, cell transformation, mutation and carcinogenesis but the underlying mechanisms remain fragmented. The present work aimed to further characterize RAR in this mouse model. In a series of recent investigations, we demonstrated that existence of RAR using different types of ionizing radiation (IR) including high LET heavy ions; increase in the hematopoietic stem cells/hematopoietic progenitor cells (HSCs/HPCs) measured as endogenous colony forming units-spleen under RAR; and reduction of delayed homologous recombination (HR) in the nucleated cells in hematopoietic tissues (bone marrow and spleen). These findings suggest that RAR in mice induced by different types of IR would share a common underlying mechanism: the priming IR-induced resistance in the blood forming tissues, leading to a protective effect on the HSCs/HPCs and rescuing the animals from bone marrow death. On the other hand, reduction of delayed HR may be at least a part of the mechanisms underlying decreased carcinogenesis by RAR. These findings provide a new insight into the mechanistic study on RAR in vivo and suggest that application of RAR would contribute to a more rigorous and scientifically-grounded system of radiation protection in radiotherapy.

This work was partially supported by both the Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research on Innovative Areas, Grant Numbers JP15K21745 and 15H05935 “Living in Space”.

Keywords:
Adaptive response, colony forming unites-spleen, homologous recombination, The 65th Annual Meeting of Radiation Research (RRS2019)に出席、ポスター発表を行う。タイトル:Study on Radioadaptive Response in a Mouse Model (Yonezawa Effect): Recent Progress},
 title = {Study on Radioadaptive Response in a Mouse Model (Yonezawa Effect): Recent Progress},
 year = {2019}
}