{"created":"2023-05-15T14:56:59.467930+00:00","id":77339,"links":{},"metadata":{"_buckets":{"deposit":"5a916a35-44d0-4672-be63-f9728b3c1087"},"_deposit":{"created_by":1,"id":"77339","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"77339"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00077339","sets":["10:29"]},"author_link":["799655","799660","799663","799664","799665","799657","799661","799662","799666","799656","799659","799658"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-11-02","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"モノアシルグリセロールリパーゼ(MAGL)は、神経炎症に関わる加水分解酵素として注目されている。これまでに我々は、アゼチジン骨格を含有するMAGL-PETリガンドを開発してきたが脳内動態が適当でなかった。今回は、アゼチジン骨格([11C]1)及びピペリジン骨格([11C]2)に置換した二種類のプローブを標識合成し、ラットにおける脳内動態について比較検討した。化合物1及び2の前駆体は5-6工程で合成し、それらをHFIPと反応させることで標品が得られた。[11C]1・2は、標識中間体である[11C]COCl2をHFIPと反応させ、アゼチジンまたはピペリジン誘導体を加えることで合成した。これらの放射化学収率は7-18%(EOS)、比放射能は49 GBq/μmolだった。ラットのPET撮像を行ったところ、[11C]1は時間の経過とともに徐々に減少し、[11C]2は投与後90分まで濃度が保持されていた。これにより、ピペリジン骨格含有化合物の方が脳内MAGLを画像化するのに適していると考えられた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第59回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"799655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原, 雄祐"}],"nameIdentifiers":[{"nameIdentifier":"799656","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"799657","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"799658","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"799659","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"799660","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Wakana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799661","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurihara, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799662","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatori, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799663","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799664","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujinaga, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799665","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"799666","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"[11C]で標識したMAGLに選択的な新規PETリガンドの合成及び動物評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"[11C]で標識したMAGLに選択的な新規PETリガンドの合成及び動物評価"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-07"},"publish_date":"2019-11-07","publish_status":"0","recid":"77339","relation_version_is_last":true,"title":["[11C]で標識したMAGLに選択的な新規PETリガンドの合成及び動物評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:49:22.212830+00:00"}