{"created":"2023-05-15T14:56:59.374669+00:00","id":77337,"links":{},"metadata":{"_buckets":{"deposit":"22c716c0-e725-48bb-88d9-84a159a4ae9a"},"_deposit":{"created_by":1,"id":"77337","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"77337"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00077337","sets":["10:29"]},"author_link":["871967","871968","871956","871950","871953","871965","871958","871964","871954","871952","871957","871951","871955","871963","871966","871962","871960","871949","871961","871959"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-11-02","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"これまでに、転移しやすいメラノーマに高発現する癌蛋白質 “代謝型グルタミン酸1型受容体（mGluR1）”に着目し、α線標的アイソトープ治療（TRT)に資する小分子放射性薬剤である211At-AITMの開発に成功した。今回、我々は211At-AITMの実用化を目指し、転移性メラノーマに対する治療検証を行った。癌蛋白質mGluR1が高発現した転移性メラノーマ担癌マウスモデルに211At-AITMあるいは生理食塩水をそれぞれ静脈投与して、治療効果及び安全性等の評価を行った。生理食塩水を投与したコントロール群（6匹）では、移植後約27.5  2.47 日にがんが進行して死亡したのに対し、11At-AITM (2.96 MBq)の単回投与による治療群（12匹）では、有意に全生存期間（61.67　 3.17日）が延長した。一方、有害事象である体重減少、血液毒性及び肝、腎機能障害などは認めなかった。α線薬剤211At-AITMは、転移性メラノーマに対し顕著な治療効果を示し、安全かつ高効率なTRT薬になりえることが示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第59回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"謝, 琳"}],"nameIdentifiers":[{"nameIdentifier":"871949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"破入, 正行"}],"nameIdentifiers":[{"nameIdentifier":"871950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"871951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"871952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"峯岸, 克行"}],"nameIdentifiers":[{"nameIdentifier":"871953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"李, 惠子"}],"nameIdentifiers":[{"nameIdentifier":"871954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"諸越, 幸恵"}],"nameIdentifiers":[{"nameIdentifier":"871955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川, 純崇"}],"nameIdentifiers":[{"nameIdentifier":"871956","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永津, 弘太郎"}],"nameIdentifiers":[{"nameIdentifier":"871957","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"871958","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xie, Lin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"871959","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hanyu, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"871960","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujinaga, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"871961","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"871962","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minegishi, Katsuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"871963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Huizi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"871964","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morokoshi, Yukie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"871965","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Sumitaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"871966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagatsu, Kotaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"871967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"871968","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"転移性メラノーマに対する211At-AITM標的アイソトープ治療薬としての実証","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"転移性メラノーマに対する211At-AITM標的アイソトープ治療薬としての実証"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-07"},"publish_date":"2019-11-07","publish_status":"0","recid":"77337","relation_version_is_last":true,"title":["転移性メラノーマに対する211At-AITM標的アイソトープ治療薬としての実証"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:51:08.160161+00:00"}