{"created":"2023-05-15T14:56:59.328611+00:00","id":77336,"links":{},"metadata":{"_buckets":{"deposit":"1a51028c-34d9-4b4b-a792-78cf2e90ed8e"},"_deposit":{"created_by":1,"id":"77336","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"77336"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00077336","sets":["10:28"]},"author_link":["803612","803610","803613","803618","803611","803614","803616","803615","803617","803619"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-11-01","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Monoacylglycerol lipase (MAGL)は、endocannabinoid systemにおいて2-arachidonoylglycerolをarachidonic acidに分解するセリン加水分解酵素である。近年、azabicyclo[3.1.0]hexane scaffoldを有するMAGL阻害剤であるPF06795071が神経炎症の治療薬として有力と報告された。我々はMAGLのPET用プローブの開発研究を進めている。今回、PFのSpirocyclic iodonium ylide前駆体に対し、求核置換反応によりベンゼン環に18Fを導入したのち、脱保護基を行い、[18F]PFを合成した。自動合成装置で得られた標識体の収率は約8％であり、放射化学純度は99％以上であった。このプローブを用いたラット脳切片のin vitroオートラジオグラフィにより、大脳皮質や線条体などの領域にMAGLに対する特異的結合が確認された。また、PETによるin vivo試験では脳への高い透過性と結合特異性を明らかにした。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第59回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"羽鳥, 晶子"}],"nameIdentifiers":[{"nameIdentifier":"803610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 若菜"}],"nameIdentifiers":[{"nameIdentifier":"803611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 一鼎"}],"nameIdentifiers":[{"nameIdentifier":"803612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永, 雅之"}],"nameIdentifiers":[{"nameIdentifier":"803613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張, 明栄"}],"nameIdentifiers":[{"nameIdentifier":"803614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatori, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"803615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Wakana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"803616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"803617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujinaga, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"803618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"803619","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Monoacylglycerol lipaseのPETプローブ[18F]PF06795071の評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Monoacylglycerol lipaseのPETプローブ[18F]PF06795071の評価"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-11-07"},"publish_date":"2019-11-07","publish_status":"0","recid":"77336","relation_version_is_last":true,"title":["Monoacylglycerol lipaseのPETプローブ[18F]PF06795071の評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:42:57.703664+00:00"}