{"created":"2023-05-15T14:56:48.929730+00:00","id":77106,"links":{},"metadata":{"_buckets":{"deposit":"69d83430-2661-4753-a41b-3208b123c4be"},"_deposit":{"created_by":1,"id":"77106","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"77106"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00077106","sets":["10:28"]},"author_link":["791244","791251","791248","791246","791249","791247","791250","791252","791245"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-05-31","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: In nonketotic hyperglycinemia (NKH), 1H-MRS shows a striking increase in brain glycine levels. However, the signal overlap of glycine with myo-inositol makes it difficult to quantify each metabolite separately. Our aim was to investigate glycine measurement with 1H-MRS using different echo times (TE) in a neonate with NKH. \nMethods: Serial single-voxel 1H-MRS in the centrum semiovale was performed with TE of 30 and 270ms in a neonate with NKH on 6, 19, 44 days of age, and the peak area ratios of glycine plus myo-inositol to creatine ((Gly+mIns)/Cr) was evaluated. Glycine levels of plasma and cerebral spinal fluid (CSF) were also measured on 5, 19, and 44 days of ages. \nResults: In both TEs, (Gly+mIns)/Cr showed higher values at first, then decreased subsequently; TE 30msec: 1.43, 1.19, and 1.11, TE 270 msec: 1.05, 0.55, and 0.49, respectively. Both glycine levels of plasma and CSF showed similar decreasing: plasma: 1803.9, 353.0, and 140.0 μmol/L, CSF: 321.6, 135.3, and 69.7 μmol/L, respectively. On 6 days, the patient was comatose, and had no spontaneous respiration. On 19 days, he was lethargic but had spontaneous respirations. On 44 days, his consciousness was almost clear.\nConclusion: The continuing reduction of (Gly+mIns)/Cr with long-TE corresponded more reliably with glycine levels of plasma and CSF than the change with short-TE. In addition to T2 relaxation time effect, myo-inositol also has J-coupling induced-dephasing effect, which results in small signal in long TE. Therefore myo-inositol signal may have a relatively less contribution to (Gly+mIns) in TE 270ms.\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 20th Annual Meeting of Infantile Seizure Society (ISS)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirose, Ayana"}],"nameIdentifiers":[{"nameIdentifier":"791244","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibasaki, Jun"}],"nameIdentifiers":[{"nameIdentifier":"791245","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomiyasu, Moyoko"}],"nameIdentifiers":[{"nameIdentifier":"791246","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumaki, Tatsuro"}],"nameIdentifiers":[{"nameIdentifier":"791247","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuyusaki, Yu"}],"nameIdentifiers":[{"nameIdentifier":"791248","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Goto, Tomohide"}],"nameIdentifiers":[{"nameIdentifier":"791249","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aida, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"791250","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomiyasu, Moyoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"791251","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aida, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"791252","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Glycine measurement using short and long echo time  proton magnetic resonance spectroscopy in a neonate with nonketotic hyperglycinemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Glycine measurement using short and long echo time  proton magnetic resonance spectroscopy in a neonate with nonketotic hyperglycinemia"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-10-09"},"publish_date":"2019-10-09","publish_status":"0","recid":"77106","relation_version_is_last":true,"title":["Glycine measurement using short and long echo time  proton magnetic resonance spectroscopy in a neonate with nonketotic hyperglycinemia"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:01:49.031798+00:00"}