{"created":"2023-05-15T14:56:41.872486+00:00","id":76944,"links":{},"metadata":{"_buckets":{"deposit":"e449e3b6-0f49-4419-b8b9-140ae1897385"},"_deposit":{"created_by":1,"id":"76944","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"76944"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00076944","sets":["10:28"]},"author_link":["786560","786562","786558","786559","786561","786557","786563"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-09-21","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[目的]早産児の新生児期における脳内代謝物濃度の予後予測能について、4歳までの発達に関する報告はあるが、それ以降の年齢については報告されていない。今回、早産児において予定日相当に撮像したMRSと6歳時の知能検査(WISC-4)の結果を比較し関連性を調査した。\n[方法]対象は52名の早産児、在胎23-36週:中央値27週1日、出生体重1500g以下:中央値985g(445-1497g)である。受胎後週数(PCA)34-40週 に3T MR装置(Siemens社)により1H-MRS(基底核、半卵円中心2.5-7.1ml; TE/TR:30/5000ms)データを収集、LCModelにより水濃度を48.9Mとし、N-アセチルアスパラギン酸(NAA)、クレアチン(Cr)、ミオ-イノシトール(Ins)、グルタミン酸+グルタミン(Glx)、コリン(Cho)の濃度を求めた。6歳時のWISC-4の結果より、全検査IQ(FSIQ)と4つの下位検査を発達良好群(IQ>85)、発達遅滞群(IQ&le;85)に分け、2群間の代謝物濃度を共分散分析(PCAを共変量)により比較しp<0.05で有意とした。\n[結果]発達良好・遅滞2群[人数, IQ中央値(範囲)]の代謝物濃度を以下に示す[中央値(範囲), mM]: 発達遅滞群[n=16, IQ80(58-85)]基底核NAA3.76(2.94-4.89), Cr5.73(4.48-6.59), Ins6.95(5.53-8.1), Glx6.68(4.44-9.02), Cho2.15(1.79-2.41); 半卵円中心NAA3.15(1.989-4.8), Cr4.11(3.38-5.17), Ins7.23(5.94-8.23), Glx5.8(4.01-8.4), Cho1.71(1.47-1.99)。発達良好群[n=36, IQ94(86-126)]基底核NAA3.45(1.89-4.96), Cr5.5(3.71-6.8), Ins6.79(4.65-8.02), Glx6.31(3.44-7.92), Cho2.16(1.39-2.47); 半卵円中心NAA2.93(2.14-4.53), Cr4.16(3.29-5.04), Ins7.36(5.99-8.59), Glx5.95(4.37-8.87), Cho1.78(1.32-2.29)。全検査IQと4つの下位検査のいずれにおいても代謝物濃度は発達良好・遅延群間で有意差はなかった。[結論]本研究ではより長期(6歳)の発達をWISC-4知能検\n査で評価し、新生児期の脳内代謝物濃度と関連性が無いことが示された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"「第47回日本磁気共鳴医学会大会」出席(教育講演発表)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"富田, 彩香"}],"nameIdentifiers":[{"nameIdentifier":"786557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柴崎, 淳"}],"nameIdentifiers":[{"nameIdentifier":"786558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"富安, もよこ"}],"nameIdentifiers":[{"nameIdentifier":"786559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"相田, 典子"}],"nameIdentifiers":[{"nameIdentifier":"786560","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"豊島, 勝昭"}],"nameIdentifiers":[{"nameIdentifier":"786561","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomiyasu, Moyoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"786562","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aida, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"786563","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Association between brain metabolite concentrations at term equivalent age in premature infants and neurodevelopment at 6 years of age","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association between brain metabolite concentrations at term equivalent age in premature infants and neurodevelopment at 6 years of age"},{"subitem_title":"早産児における予定日相当の脳内代謝物濃度と6歳時知能検査 (WISC-4)の関連性","subitem_title_language":"en"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-27"},"publish_date":"2019-09-27","publish_status":"0","recid":"76944","relation_version_is_last":true,"title":["Association between brain metabolite concentrations at term equivalent age in premature infants and neurodevelopment at 6 years of age"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:08:37.833853+00:00"}