@article{oai:repo.qst.go.jp:00076763,
 author = {Eden, Dominique and Gros, Charley and Badji, Atef and M Dupont, Sara and De Leener, Benjamin and Maranzano, Josefina and Zhuoquiong, Ren and Liu, Yaou and Granberg, Tobias and Ouellette, Russell and Stawiarz, Leszek and Hillert, Jan and Talbott, Jason and Bannier, Elise and Kerbrat, Anne and Edan, Gilles and Labauge, Pierre and Callot, Virginie and Pelletier, Jean and Audoin, Bertrand and Rasoanandrianina, Henitsoa and Jean-Christophe, Brisset and Valsasina, Paola and A Rocca, Maria and Filippi, Massimo and Bakshi, Rohit and Tauhid, Shahamat and Prados, Ferran and Yiannakas, Marios and Kearney, Hugh and Ciccarelli, Olga and A Smith, Seth and Andrada Treaba, Constantina and Mainero, Caterina and Lefeuvre, Jennifer and S Reich, Daniel and Nair, Govind and M Shepherd, Timothy and Charlson, Erik and Tachibana, Yasuhiko and Hori, Masaaki and Kamiya, Kouhei and Chougar, Lydia and Narayanan, Sridar and Julien, Cohen-Adad and Yasuhiko, Tachibana},
 issue = {3},
 journal = {Brain : a journal of neurology},
 month = {Jan},
 note = {Spinal cord lesions detected on MRI hold important diagnostic and prognostic value for multiple sclerosis. Previous attempts to correlate lesion burden with clinical status have had limited success, however, suggesting that lesion location may be a contributor. Our aim was to explore the spatial distribution of multiple sclerosis lesions in the cervical spinal cord, with respect to clinical status. We included 642 suspected or confirmed multiple sclerosis patients (31 clinically isolated syndrome, and 416 relapsing-remitting, 84 secondary progressive, and 73 primary progressive multiple sclerosis) from 13 clinical sites. Cervical spine lesions were manually delineated on T2- and T2*-weighted axial and sagittal MRI scans acquired at 3 or 7 T. With an automatic publicly-available analysis pipeline we produced voxelwise lesion frequency maps to identify predilection sites in various patient groups characterized by clinical subtype, Expanded Disability Status Scale score and disease duration. We also measured absolute and normalized lesion volumes in several regions of interest using an atlas-based approach, and evaluated differences within and between groups. The lateral funiculi were more frequently affected by lesions in progressive subtypes than in relapsing in voxelwise analysis (P < 0.001), which was further confirmed by absolute and normalized lesion volumes (P < 0.01). The central cord area was more often affected by lesions in primary progressive than relapse-remitting patients (P < 0.001). Between white and grey matter, the absolute lesion volume in the white matter was greater than in the grey matter in all phenotypes (P < 0.001); however when normalizing by each region, normalized lesion volumes were comparable between white and grey matter in primary progressive patients. Lesions appearing in the lateral funiculi and central cord area were significantly correlated with Expanded Disability Status Scale score (P < 0.001). High lesion frequencies were observed in patients with a more aggressive disease course, rather than long disease duration. Lesions located in the lateral funiculi and central cord area of the cervical spine may influence clinical status in multiple sclerosis. This work shows the added value of cervical spine lesions, and provides an avenue for evaluating the distribution of spinal cord lesions in various patient groups.},
 pages = {633--646},
 title = {Spatial distribution of multiple sclerosis lesions in the cervical spinal cord.},
 volume = {142},
 year = {2019}
}