{"created":"2023-05-15T14:56:27.449885+00:00","id":76668,"links":{},"metadata":{"_buckets":{"deposit":"f972f13a-fbbc-4107-8617-673c2813a70c"},"_deposit":{"created_by":1,"id":"76668","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"76668"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00076668","sets":["1"]},"author_link":["848326","848323","848324","848321","848327","848325","848322","848331","848330","848328","848329"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"188","bibliographicPageStart":"178","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research　"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effects of the charged ion species 4He, 12C and 20Ne on glioblastoma multiforme (GBM) T98G, U87 and LN18 cell lines were compared with the effects of 200 kVp X-rays (1.7 keV/μm). These cell lines have different genetic profiles. Individual GBM relative biological effectiveness (RBE) was estimated in two ways: the RBE10 at 10% survival fraction and the RBE2 Gy after 2 Gy doses. The linear quadratic model radiosensitivity parameters α and β and the α/β ratio of each ion type were determined as a function of LET. Mono-energetic 4\nHe, 12C and 20Ne ions were generated by the Heavy Ion Medical Accelerator at the National Institute of Radiological Sciences in Chiba, Japan. Colony-formation\nassays were used to evaluate the survival fractions. The LET of the various ions used ranged from 2.3 to 100 keV/μm (covering the depth–dose plateau region to clinically relevant LET at the Bragg peak). For U87 and LN18, the RBE10\nincreased with LET and peaked at 85 keV/μm, whereas T98G peaked at 100 keV/μm. All three GBM α parameters peaked at 100 keV/μm. There is a statistically significant difference between the three GBM RBE10 values, except at 100 keV/μm (P < 0.01), and a statistically significant difference between the α values of the GBM cell lines, except at 85 and 100 keV/μm. The biological response varied depending on the GBM cell lines and on the ions used.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/jrr/rry099","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://academic.oup.com/jrr/article/60/2/178/5280421","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1349-9157","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsuey Chew, Ming"}],"nameIdentifiers":[{"nameIdentifier":"848321","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"David A., Bradley"}],"nameIdentifiers":[{"nameIdentifier":"848322","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Masao"}],"nameIdentifiers":[{"nameIdentifier":"848323","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsufuji, Naruhiro"}],"nameIdentifiers":[{"nameIdentifier":"848324","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"848325","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bleddyn, Jones"}],"nameIdentifiers":[{"nameIdentifier":"848326","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Andrew, Nisbet"}],"nameIdentifiers":[{"nameIdentifier":"848327","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuey Chew, Ming","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"848328","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Masao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"848329","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsufuji, Naruhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"848330","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"848331","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The radiobiological effects of He, C and Ne ions as a function of LET on various glioblastoma cell lines","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The radiobiological effects of He, C and Ne ions as a function of LET on various glioblastoma cell lines"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-05"},"publish_date":"2019-09-05","publish_status":"0","recid":"76668","relation_version_is_last":true,"title":["The radiobiological effects of He, C and Ne ions as a function of LET on various glioblastoma cell lines"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:33:05.841524+00:00"}