{"created":"2023-05-15T14:56:25.596327+00:00","id":76640,"links":{},"metadata":{"_buckets":{"deposit":"422bb780-d23d-48c3-9a43-afed037500ec"},"_deposit":{"created_by":1,"id":"76640","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"76640"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00076640","sets":["10:28"]},"author_link":["846812","846814","846813","846815"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-08-26","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It is well-known that DNA lesions induced by ionizing radiation and chemicals can cause mutation and carcinogenesis. In particular, “clustered damage\" site, that is a DNA region with multiple lesions within a few helical turns, is believed to hardly be repaired. This type of damage is considered to be induced around high-LET radiation tracks and at a track-end of secondary electron. However, chemical and spatial details of them are not known. We have developed a methodology for estimating localization of the lesions using fluorescence anisotropy. The fluorescence anisotropy generally decreases with increasing Förster resonance energy transfer (FRET) efficiency. We found that experimentally-obtained anisotropy for the heat-treated DNA correspond to theoretical ones calculated on the basis of exponential distribution. Now we are applying the methodology based on fluorescence anisotropy to liner-formed pUC19 irradiated with radiation such as Co-60 gamma-rays, helium, carbon, and Fe ion beams. The results and the prospective will be discussed.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"ICRR(International Congress on Radiation Research) 2019","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Akamatsu, Ken"}],"nameIdentifiers":[{"nameIdentifier":"846812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shikazono, Naoya"}],"nameIdentifiers":[{"nameIdentifier":"846813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akamatsu, Ken","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"846814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shikazono, Naoya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"846815","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Study of radiation-induced clustered DNA damage by fluorescence anisotropy measurement based on Förster resonance energy transfer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Study of radiation-induced clustered DNA damage by fluorescence anisotropy measurement based on Förster resonance energy transfer"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-09-03"},"publish_date":"2019-09-03","publish_status":"0","recid":"76640","relation_version_is_last":true,"title":["Study of radiation-induced clustered DNA damage by fluorescence anisotropy measurement based on Förster resonance energy transfer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:35:26.040902+00:00"}