@article{oai:repo.qst.go.jp:00076526,
 author = {Nakamura, Mizuki and Yamasaki, Toshihide and Ueno, Megumi and Shibata, Sayaka and Ozawa, Yoshikazu and Kamada, Tadashi and Nakanishi, Ikuo and Ken-ichi, Yamada and Aoki, Ichio and Ken-ichiro, Matsumoto and Nakamura, Mizuki and Yamasaki, Toshihide and Ueno, Megumi and Shibata, Sayaka and Ozawa, yoshikazu and Kamada, Tadashi and Nakanishi, Ikuo and Aoki, Ichio and Matsumoto, Kenichiro},
 journal = {Free Radical Biology and Medicine},
 month = {Aug},
 note = {Time courses of the redox status in the brains of mice after X-ray or carbon-ion beam irradiation were observed by magnetic resonance redox imaging (MRRI). The relationship between radiation-induced oxidative stress on the cerebral nervous system and the redox status in the brain was discussed. 
The mice were irradiated by 8-Gy X-ray or carbon-ion beam (C-beam) on their head under anesthesia. C-beam irradiation was performed at HIMAC (Heavy-Ion Medical Accelerator in Chiba, NIRS/QST, Chiba, Japan). MRRI measurements using a blood-brain-barrier-permeable nitroxyl contrast agent, MCP or TEMPOL, were performed using 7-T scanner at several different times, i.e., 5-10 hours, 1, 2, 4, and 8 day(s) after irradiation. Decay rates of the nitroxyl-enhanced T1-weighted MR signals in the brains were estimated from MRRI data sets, and variation in the decay rates after irradiation was assessed.
The variation in decay rates of MCP and TEMPOL after X-ray or C-beam irradiation was similar, but different variation patterns were observed between X-ray and C-beam. The apparent decay rate of both MCP and TEMPOL decreased due to the temporal reduction of blood flow in the brain several hours after X-ray and/or C-beam irradiation. After decreasing, the apparent decay rates of nitroxyl radicals in the brain gradually increased during the following days after X-ray irradiation or rapidly increased 1 day after C-beam irradiation. The sequential increase in nitroxyl decay rates may have been due to the oxidative atmosphere in the tissue due to ROS generation. X-ray and C-beam irradiation resulted in different redox responses, which may have been due to time-varying oxidative stress/injury, in the mouse brain. The C-beam irradiation effects were more acute and larger than those of X-ray irradiation.},
 pages = {412--421},
 title = {Radiation-Induced Redox Alteration in the Mouse Brain},
 volume = {143},
 year = {2019}
}