{"created":"2023-05-15T14:56:18.964401+00:00","id":76490,"links":{},"metadata":{"_buckets":{"deposit":"d810d232-e28f-4488-9b07-552aa2857ca3"},"_deposit":{"created_by":1,"id":"76490","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"76490"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00076490","sets":["10:28"]},"author_link":["820648","820646","820645","820647"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-08-08","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"私たちヒトを含む真核生物のDNAは、細胞核内にヌクレオソームとしてコンパクトに収納されている。ヌクレオソームに収納されたDNAは、細胞核内のさまざまなタンパク質や核酸との相互作用によって、捩れのストレスを受ける。特に、RNAポリメラーゼによって、DNAがmRNAに転写される際には、ポリメラーゼの下流のDNAが overtwist し、上流のDNAは undertwist することが知られている。本研究では、このストレスがヌクレオソームの構造安定性に与える影響を、大規模なシミュレーションによって明らかにした。その結果を報告した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"ポスト「京」重点課題1×重点課題2シンポジウム","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河野, 秀俊"}],"nameIdentifiers":[{"nameIdentifier":"820645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石田, 恒"}],"nameIdentifiers":[{"nameIdentifier":"820646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kono, Hidetoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"820647","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishida, Hisashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"820648","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"トルク作用条件下におけるヌクレオソームDNAの解離自由エネルギー解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"トルク作用条件下におけるヌクレオソームDNAの解離自由エネルギー解析"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-08-13"},"publish_date":"2019-08-13","publish_status":"0","recid":"76490","relation_version_is_last":true,"title":["トルク作用条件下におけるヌクレオソームDNAの解離自由エネルギー解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:18:37.683096+00:00"}