{"created":"2023-05-15T14:56:18.652201+00:00","id":76482,"links":{},"metadata":{"_buckets":{"deposit":"8fa3b226-280d-44e3-9238-8e88086f92d1"},"_deposit":{"created_by":1,"id":"76482","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"76482"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00076482","sets":["1"]},"author_link":["909057","909062","909053","909059","909056","909060","909055","909058","909061","909054"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":" 8","bibliographicPageEnd":"3616","bibliographicPageStart":"3609","bibliographicVolumeNumber":" 16","bibliographic_titles":[{"bibliographic_title":"Molecular Pharmaceutics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Positron emission tomography (PET) imaging with 18F-labeled α-methyl-substituted amino acids exerts significant influence on differential diagnosis of malignant tumors and tumor-like lesions. We newly designed 18F-labeled α-methyl-phenylalanine (18F-FAMP) regioisomers (2-, 3-, or 4-18F-FAMP) and stereoisomers (L- or D-form), and we evaluated their potential as tumor-imaging agents. In tumor bearing mice, L-2-18F-FAMP exhibited significantly higher tumor accumulation than the D-18F-FAMPs or a clinically relevant tracer, L-3-18F-α-methyl-tyrosine (18F-FAMT) (p < 0.05). Specificity of L-2-18F-FAMP for L-type amino acid transporter-1, a tumor-specific transporter, was validated in the cellular uptake studies. The PET imaging with L-2-18F-FAMP clearly visualized the tumor as early as 1 h after injection, and the high tumor accumulation level was retained for 3 h. These findings suggest that L-2-18F-FAMP constitutes a potential PET tracer for tumor-specific imaging.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ACS Publications"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1021/acs.molpharmaceut.9b00446","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00446","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1543-8384","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"花岡, 宏史 群馬大学大学院医学系研究科"}],"nameIdentifiers":[{"nameIdentifier":"909053","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oshima, Yasuhiro"}],"nameIdentifiers":[{"nameIdentifier":"909054","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山口, 藍子 群馬大学大学院医学系研究科"}],"nameIdentifiers":[{"nameIdentifier":"909055","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 博元 千葉大学大学院薬学研究院"}],"nameIdentifiers":[{"nameIdentifier":"909056","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishioka, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"909057","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口, 徹也 群馬大学大学院医学系研究科"}],"nameIdentifiers":[{"nameIdentifier":"909058","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒野, 泰   千葉大学大学院薬学研究院"}],"nameIdentifiers":[{"nameIdentifier":"909059","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"対馬, 義人 群馬大学大学院医学系研究科"}],"nameIdentifiers":[{"nameIdentifier":"909060","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oshima, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"909061","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishioka, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"909062","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Novel 18F‑Labeled α‑Methyl-Phenylalanine Derivative with High Tumor Accumulation and Ideal Pharmacokinetics for Tumor-Specific Imaging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Novel 18F‑Labeled α‑Methyl-Phenylalanine Derivative with High Tumor Accumulation and Ideal Pharmacokinetics for Tumor-Specific Imaging"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-08-02"},"publish_date":"2019-08-02","publish_status":"0","recid":"76482","relation_version_is_last":true,"title":["Novel 18F‑Labeled α‑Methyl-Phenylalanine Derivative with High Tumor Accumulation and Ideal Pharmacokinetics for Tumor-Specific Imaging"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:06:14.086573+00:00"}