{"created":"2023-05-15T14:56:03.181576+00:00","id":76124,"links":{},"metadata":{"_buckets":{"deposit":"5fe08b06-6b8f-4f67-963b-4a960a6a58a4"},"_deposit":{"created_by":1,"id":"76124","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"76124"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00076124","sets":["10:28"]},"author_link":["765861","765858","765860","765862","765859"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-05-28","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives. [11C]Cyanide is a useful intermediate for labelling functional groups such as CN, COOH, CONH2 and CH2NH2 in organic compounds. Conventional method for the preparation of [11C]cyanide, however, requires dedicated infrastructure. [11C]Cyanide is generally prepared by heating [11C]CH4 under NH3 gas flow at more than 900°C over a platinum filled column. Furthermore, the starting material, [11C]CH4, is produced by the irradiation of N2/H2 gas or by heating [11C]CO2 under H2 gas flow over nickel. In the previous meeting (ISRS2017), we reported that [11C]cyanide was prepared by the dehydration of [11C]formaldoxime, though the radiochemical yield was insufficient (around 20% from [11C]CO2). Thus, we explored more efficient method to prepare [11C]cyanide without any special equipment and reagents. In this study, we investigated the applicability of hydroxylamine-O-sulfonic acid (HOSA) to [11C]cyanide preparation from [11C]CH3I which is widely used for 11C-labelling. HOSA has been used as a reagent for the conversion of aldehydes into nitriles.\nMethods. [11C]CH3I (300–400 MBq) was trapped in a 1 mL of trimethylammonium oxide (TMAO, 15 mg) solution in DMF or DMSO and heated for 2 min to prepare [11C]HCHO (at 70°C for DMF solution, at 100°C for DMSO solution). The [11C]HCHO solution (200 μL) was subsequently added to the HOSA solution in the corresponding solvents (200 μL). The reaction conditions are summarized in Table 1. Radiochemical yields from [11C]CH3I were determined by radio-HPLC analysis of the reaction solution. More than 87% of radioactivity in the injected solution was eluted during the HPLC analysis.\nResults. The results are summarized in Table 1. Higher reaction temperature enhanced the formation of [11C]cyanide. The use of DMSO showed better yield of [11C]cyanide compared with DMF. The use of more than 1 equivalent of HOSA based on the amount of TMAO was required to obtain good yields of [11C]cyanide. Consequently, [11C]cyanide was produced in 87% radiochemical yield after 3 min reaction time.\nConclusions. [11C]Cyanide was efficiently prepared from [11C]CH3I in one-pot using conventional reagents and lab-ware. Further optimization of reaction conditions for the production of [11C]cyanide with an automated system is in progress.\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"ISRS2019 (The 23rd International Symposium on Radiopharmaceutical Sciences)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kikuchi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"765858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"765859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"D.Gee, Antony"}],"nameIdentifiers":[{"nameIdentifier":"765860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kikuchi, Tatsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"765861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"765862","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"A facile method for the preparation of [11C]cyanide from [11C]methyl iodide","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A facile method for the preparation of [11C]cyanide from [11C]methyl iodide"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-05-30"},"publish_date":"2019-05-30","publish_status":"0","recid":"76124","relation_version_is_last":true,"title":["A facile method for the preparation of [11C]cyanide from [11C]methyl iodide"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:35:37.867725+00:00"}