{"created":"2023-05-15T14:55:56.767872+00:00","id":75972,"links":{},"metadata":{"_buckets":{"deposit":"e97cd8a4-b07c-4fc5-9b9a-eb1c204c58d4"},"_deposit":{"created_by":1,"id":"75972","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"75972"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00075972","sets":["1"]},"author_link":["893107","893109","893105","893106","893104","893102","893103","893111","893108","893110"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"2394","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Nature Communications"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To understand the molecular processes that link Aβ amyloidosis, tauopathy and neurodegeneration, we screened for tau-interacting proteins by immunoprecipitation/LC-MS. We identified the carboxy-terminal PDZ ligand of nNOS (CAPON) as a novel tau-binding protein. CAPON is an adaptor protein of neuronal nitric oxide synthase (nNOS), and activated by the N-methyl-D-aspartate receptor. We observed accumulation of CAPON in the hippocampal pyramidal cell layer in the AppNL-G-F -knock-in (KI) brain. To investigate the effect of CAPON accumulation on Alzheimer’s disease (AD) pathogenesis, CAPON was overexpressed in the brain of AppNL-G-F mice crossbred with MAPT (human tau)-KI mice. This produced significant hippocampal atrophy and caspase3-dependent neuronal cell death in the CAPON-expressing hippocampus, suggesting that CAPON accumulation increases neurodegeneration. CAPON expression also induced significantly higher levels of phosphorylated, oligomerized and insoluble tau. In contrast, CAPON deficiency ameliorated the AD-related pathological phenotypes in tauopathy model. These findings suggest that CAPON could be a druggable AD target.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature.com"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31160584","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41467-019-10278-x","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41467-019-10278-x","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hashimoto, Shoko"}],"nameIdentifiers":[{"nameIdentifier":"893102","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuba, Yukio"}],"nameIdentifiers":[{"nameIdentifier":"893103","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamano, Naoko"}],"nameIdentifiers":[{"nameIdentifier":"893104","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MIhira, Naomi"}],"nameIdentifiers":[{"nameIdentifier":"893105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sahara, Naruhiko"}],"nameIdentifiers":[{"nameIdentifier":"893106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Jiro"}],"nameIdentifiers":[{"nameIdentifier":"893107","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shin-ichi, Muramatsu"}],"nameIdentifiers":[{"nameIdentifier":"893108","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"C. Saido, Takaomi"}],"nameIdentifiers":[{"nameIdentifier":"893109","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"893110","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sahara, Naruhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"893111","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tau binding protein CAPON induces tau aggregation and neurodegeneration ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tau binding protein CAPON induces tau aggregation and neurodegeneration "}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-04"},"publish_date":"2019-06-04","publish_status":"0","recid":"75972","relation_version_is_last":true,"title":["Tau binding protein CAPON induces tau aggregation and neurodegeneration "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:26:34.751192+00:00"}