{"created":"2023-05-15T14:55:56.638162+00:00","id":75969,"links":{},"metadata":{"_buckets":{"deposit":"ee7674eb-184d-4b60-b744-16f79f456043"},"_deposit":{"created_by":1,"id":"75969","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"75969"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00075969","sets":["1"]},"author_link":["865541","865537","865538","865542","865543","865539","865540"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"702","bibliographicPageStart":"698","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"Bioconjugate Chemistry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Artificially modified IgG molecules are increasingly utilized in industrial and clinical applications. In the present study, the method of chemical conjugation by affinity peptide (CCAP) for site-specific chemical modification has been developed by using a peptide that bound with high affinity to human IgG-Fc. This method enabled a rapid modification of a specific residue (Lys248 on Fc) in a one-step reaction under mild condition to form a stable amide bond between the peptide and Fc. The monovalent peptide-IgG conjugate not only maintained complete antigen binding but also bound to Fc receptors (FcRn, FcγRI, and FcγRIIIa), indicating that it is a suitable conjugate form that can be further developed into highly functional antibody therapeutics. CCAP was applied for the preparation of an antibody-drug conjugate and a bispecific antibody to demonstrate the usefulness of this method.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ACS publications"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"30616340","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1021/acs.bioconjchem.8b00865","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://pubs.acs.org/doi/10.1021/acs.bioconjchem.8b00865","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1043-1802","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kishimoto, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"865537","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakashimada, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"865538","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokota, Riri"}],"nameIdentifiers":[{"nameIdentifier":"865539","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatanaka, Takaaki"}],"nameIdentifiers":[{"nameIdentifier":"865540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安達, 基泰"}],"nameIdentifiers":[{"nameIdentifier":"865541","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"865542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Adachi, Motoyasu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"865543","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Site-Specific Chemical Conjugation of Antibodies by Using Affinity Peptide for the Development of Therapeutic Antibody Format","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Site-Specific Chemical Conjugation of Antibodies by Using Affinity Peptide for the Development of Therapeutic Antibody Format"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-04"},"publish_date":"2019-06-04","publish_status":"0","recid":"75969","relation_version_is_last":true,"title":["Site-Specific Chemical Conjugation of Antibodies by Using Affinity Peptide for the Development of Therapeutic Antibody Format"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:58:20.039985+00:00"}