{"created":"2023-05-15T14:55:56.286845+00:00","id":75961,"links":{},"metadata":{"_buckets":{"deposit":"bfa07323-27b8-4b70-a376-76daac9517ca"},"_deposit":{"created_by":1,"id":"75961","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"75961"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00075961","sets":["1"]},"author_link":["894073","894075","894074"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"180","bibliographicPageEnd":"J75","bibliographicPageStart":"J69","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"Trends in Glycoscience and Glycotechnology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"核やミトコンドリア、細胞質に存在する種々のタンパク質は、セリン／スレオニン残基にN-アセチルグルコサミン（GlcNAc）が1 分子結合したO-GlcNAc（O-結合型N-アセチルグルコサミン）修飾を受けている。O-GlcNAc修飾を受けるタンパク質は、シグナル構成因子、転写因子、エピジェネティック制御因子、ヒストンなど多種多様であることが明らかにされている。O-GlcNAcの機能も多種多様で、リン酸化抑制、転写活性の調節、タンパク質の安定化、細胞内局在の調節などがある。近年、マウス／ヒトの多能性幹細胞において、O-GlcNAcは未分化／分化状態を調節する主要因子として注目され始めており、O-GlcNAcの機能について徐々に明らかにされている。本稿では、マウス／ヒトの多能性幹細胞におけるO-GlcNAcの多彩な機能を紹介する。","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"FCCA"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.4052/tigg.1954.2J","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/tigg/31/180/31_1954.2J/_article/-char/ja/","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0915-7352","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三浦, 太一"}],"nameIdentifiers":[{"nameIdentifier":"894073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西原, 祥子"}],"nameIdentifiers":[{"nameIdentifier":"894074","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miura, Taichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"894075","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"多能性幹細胞におけるＯ-GlcNAcの機能","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"多能性幹細胞におけるＯ-GlcNAcの機能"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-06-03"},"publish_date":"2019-06-03","publish_status":"0","recid":"75961","relation_version_is_last":true,"title":["多能性幹細胞におけるＯ-GlcNAcの機能"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:25:23.510346+00:00"}