{"created":"2023-05-15T14:55:54.517474+00:00","id":75920,"links":{},"metadata":{"_buckets":{"deposit":"ff935f7a-06ea-463d-8f76-d89e6e154c7d"},"_deposit":{"created_by":1,"id":"75920","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"75920"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00075920","sets":["10:28"]},"author_link":["818345","818337","818341","818344","818346","818340","818336","818347","818339","818338","818342","818348","818343","818349"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-05-23","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【背景】腫瘍内微小環境における不完全血管の新生や低酸素領域の形成は、化学療法剤の送達不全、放射線治療の耐性化に関わる主要な因子の一つであり、その病態解明や改善方法の確立は、治療効果の向上に不可欠である。本研究では、各種イメージング法により腫瘍内微小環境の多角的評価を実施し、含硫糖脂質 SQAP が in vivo のみで誘発する放射線増感効果の作用メカニズムを、腫瘍の血管新生や酸素動態などの生理学的特性に着目して調べた。\n【方法】SQAP (2 mg/kg) を SCCVII あるいは A549 担癌マウスへ尾静注し、必要に応じて X 線 (2 Gy) を照射後、電子スピン共鳴酸素イメージング、光音響画像解析、Gd-DTPA を用いた DCE-MRI (T1) および微小超常磁性酸化鉄粒子 (USPIO) を用いた MRI (T2) により、腫瘍内酸素分圧 (pO2)、血中酸素飽和度 (sO2)、腫瘍内還流、微小血管密度の変化を経時経日的に追跡した。\n【結果】尾静注された SQAP は、①赤血球からの酸素分子の放出促進作用 (sO2 低下: ~15%) および②腫瘍組織内の還流上昇作用 (~110%) を示すことが判明し、投与 20-30 分後には腫瘍内 pO2 が最大で 7.8 mmHg 上昇した。このタイミングで X 線を照射すると、その酸素効果が増大し、治療効果が増強される可能性が示唆された。また、併用治療を 3 日間毎日継続した後の腫瘍では、その生育速度が遅延するとともに、低酸素化の抑制、微小血管の消失、血管周皮細胞の一過的発現など、腫瘍血管の正常化 (Vascular normalization) を示唆する所見が認められた。\n【結論】各種 in vivo 分子イメージングにより腫瘍内微小環境の生理学的特性を多角的に評価し、in vitro 実験では解析困難な生理学的変化に起因する SQAP の放射線増感作用のメカニズムを解明した。含硫糖脂質としては初の知見となる本生物活性を基盤に、GLP 準拠の製剤化 (Lavurchin®, M.T.3 社) や毒性試験が終了し、患畜薬としての臨床研究および治験準備が進行中である。\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第 14 回日本分子イメージング学会総会・学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takakusagi, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"818336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Shingo"}],"nameIdentifiers":[{"nameIdentifier":"818337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuo, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"818338","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takakusagi, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"818339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Keita"}],"nameIdentifiers":[{"nameIdentifier":"818340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kishimoto, Shun"}],"nameIdentifiers":[{"nameIdentifier":"818341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miura, Masahiko"}],"nameIdentifiers":[{"nameIdentifier":"818342","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyazaki, Toshiyasu"}],"nameIdentifiers":[{"nameIdentifier":"818343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugawara, Fumio"}],"nameIdentifiers":[{"nameIdentifier":"818344","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakaguchi, Kengo"}],"nameIdentifiers":[{"nameIdentifier":"818345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"B Mitchell, James"}],"nameIdentifiers":[{"nameIdentifier":"818346","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"C Krishna, Murali"}],"nameIdentifiers":[{"nameIdentifier":"818347","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takakusagi, Yoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818348","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takakusagi, Kaori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"818349","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"A multimodal molecular imaging study of tumor microenvironment to reveal the mechanism of tumor radiosensitization elicited by a natural sulfoglycolipid","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A multimodal molecular imaging study of tumor microenvironment to reveal the mechanism of tumor radiosensitization elicited by a natural sulfoglycolipid"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-05-28"},"publish_date":"2019-05-28","publish_status":"0","recid":"75920","relation_version_is_last":true,"title":["A multimodal molecular imaging study of tumor microenvironment to reveal the mechanism of tumor radiosensitization elicited by a natural sulfoglycolipid"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:22:59.747557+00:00"}