{"created":"2023-05-15T14:55:50.351535+00:00","id":75822,"links":{},"metadata":{"_buckets":{"deposit":"dfccfaf0-df10-495b-afad-87870f024ee1"},"_deposit":{"created_by":1,"id":"75822","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"75822"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00075822","sets":["1"]},"author_link":["849557","849567","849573","849556","849561","849563","849572","849569","849570","849568","849571","849562","849565","849558","849564","849560","849566","849559"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"468","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Cancers"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although conventional radiotherapy promotes the migration/invasion of cancer stem cells (CSCs) under normoxia, carbon ion (C-ion) irradiation actually decreases these processes. Unraveling the mechanisms of this discrepancy, particularly under the hypoxic conditions that pertain in niches where CSCs are preferentially localized, would provide a better understanding of the origins of metastases. Invasion/migration, proteins involved in epithelial-to-mesenchymal transition (EMT), and expression of MMP-2 and HIF-1α were quantified in the CSC subpopulations of two head-and-neck squamous cell carcinoma (HNSCC) cell lines irradiated with X-rays or C-ions. X-rays triggered HNSCC-CSC migration/invasion under normoxia, however this effect was significantly attenuated under hypoxia. C-ions induced fewer of these processes in both oxygenation conditions. The differential response to C-ions was associated with a lack of HIF-1α stabilization, MMP-2 expression, or activation of kinases of the main EMT signaling pathways. Furthermore, we demonstrated a major role of reactive oxygen species (ROS) in the triggering of invasion/migration in response to X-rays. Monte-Carlo simulations demonstrated that HO・ radicals are quantitatively higher after C-ions than after X-rays, however they are very differently distributed within cells. We postulate that the uniform distribution of ROS after X-rays induces the mechanisms leading to invasion/migration, which ROS concentrated in C-ion tracks are unable to trigger.\n","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/cancers11040468","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521340/","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2072-6694","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"WOZNY, Anne-Sophie"}],"nameIdentifiers":[{"nameIdentifier":"849556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Vares, Guillaume"}],"nameIdentifiers":[{"nameIdentifier":"849557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gersende, ALPHONSE"}],"nameIdentifiers":[{"nameIdentifier":"849558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lauret, Alexandra"}],"nameIdentifiers":[{"nameIdentifier":"849559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Monini, Caterina"}],"nameIdentifiers":[{"nameIdentifier":"849560","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Magne, Nicolas"}],"nameIdentifiers":[{"nameIdentifier":"849561","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Cuerq, Charlotte"}],"nameIdentifiers":[{"nameIdentifier":"849562","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤森, 亮"}],"nameIdentifiers":[{"nameIdentifier":"849563","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jean-Claude, Monboisse"}],"nameIdentifiers":[{"nameIdentifier":"849564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Beuve, Michael"}],"nameIdentifiers":[{"nameIdentifier":"849565","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島, 徹夫"}],"nameIdentifiers":[{"nameIdentifier":"849566","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"RODRIGUEZ-LAFRASSE, Claire"}],"nameIdentifiers":[{"nameIdentifier":"849567","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wozny, Annesophie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"849568","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Vares, Guillaume","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"849569","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Alphonse, Gersende","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"849570","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimori, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"849571","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Tetsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"849572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Rodriguezlafrasse, Claire","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"849573","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ROS Production and Distribution: A New Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on Cancer Stem Cell Migration and Invasion","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ROS Production and Distribution: A New Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on Cancer Stem Cell Migration and Invasion"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-05-14"},"publish_date":"2019-05-14","publish_status":"0","recid":"75822","relation_version_is_last":true,"title":["ROS Production and Distribution: A New Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on Cancer Stem Cell Migration and Invasion"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:31:22.736082+00:00"}