{"created":"2023-05-15T14:55:48.909314+00:00","id":75788,"links":{},"metadata":{"_buckets":{"deposit":"949f24cb-79b6-4194-834f-f3af0fd793c3"},"_deposit":{"created_by":1,"id":"75788","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"75788"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00075788","sets":["1"]},"author_link":["942511","942499","942497","942500","942506","942501","942509","942504","942502","942508","942507","942513","942503","942510","942516","942498","942515","942514","942505","942512","942496"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"66","bibliographicPageStart":"55","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"The Open Biomedical Engineering Journal"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background:\nWe previously reported that among cases clinically diagnosed with Alzheimer’s disease, the proportion of amyloid beta (Aβ) -negative case\nincreases in the elderly population. Tauopathy including Argyrophilic Grain Disease (AGD) and Neurofibrillary Tangle-Predominant Dementia\n(NFTPD), may be the leading causes of such dementia.\nObjective:\nTo evaluate the involvement of tau, we studied tau accumulation in Amyloid-Negative Dementia Cases in the Elderly (ANDE) with Positron\nEmission Tomography (PET).\nMethods:\nSeven cases with slowly progressive dementia who were older than 80 years and were negative for Aβ were studied. In one case, autopsy obtained\n2 years after the PET examination revealed neurofibrillary tangles limited around the parahippocampal gyrus. Four cases showed strong laterality\nin magnetic resonance imaging atrophy (clinical AGD), while the other three cases had no significant laterality in atrophy (clinical NFTPD). Agecorrected\nPET data of healthy controls (HC; n = 12) were used as control. Tau accumulation was evaluated with [11C]PBB3-PET.\nResults:\nHigh accumulation was found in the lateral temporal cortex in ANDE. In autopsy case, scattered neurofibrillary tangles were found in the\nparahippocampal gyrus. In addition, there was a very high accumulation of PBB3 in the large area of bilateral parietal lobes, although no\ncorresponding tau component was found in the autopsied case.\nConclusion:\nRelatively high burden of tau deposition was commonly observed in the lateral temporal cortex and parietal cortex of ANDE, part of which may\nexplain dementia in these subjects. [11C]PBB3 may be useful in detecting tauopathy in ANDE.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Bentham Science Publishers"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2174/1874120701913010055","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://benthamopen.com/contents/pdf/TOBEJ/TOBEJ-13-55.pdf","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1874-1207","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takeuchi, Jun"}],"nameIdentifiers":[{"nameIdentifier":"942496","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kikukawa, Takayuki"}],"nameIdentifiers":[{"nameIdentifier":"942497","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Haruna"}],"nameIdentifiers":[{"nameIdentifier":"942498","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Itsuki"}],"nameIdentifiers":[{"nameIdentifier":"942499","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeda, Akitoshi"}],"nameIdentifiers":[{"nameIdentifier":"942500","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatsuta, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"942501","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawabe, Joji"}],"nameIdentifiers":[{"nameIdentifier":"942502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wada, Yasuhiro"}],"nameIdentifiers":[{"nameIdentifier":"942503","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mawatari, Aya"}],"nameIdentifiers":[{"nameIdentifier":"942504","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Igesaka, Ami"}],"nameIdentifiers":[{"nameIdentifier":"942505","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Doi, Hisashi"}],"nameIdentifiers":[{"nameIdentifier":"942506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Yasuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"942507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"942508","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Soichiro"}],"nameIdentifiers":[{"nameIdentifier":"942509","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"942510","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"942511","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Itoh, Yoshiaki"}],"nameIdentifiers":[{"nameIdentifier":"942512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hitoshi, Shimada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"942513","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Soichiro, Kitamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"942514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makoto, Higuchi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"942515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tetsuya, Suhara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"942516","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Amyloid-Negative Dementia in the Elderly is Associated with High Accumulation of Tau in the Temporal Lobes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Amyloid-Negative Dementia in the Elderly is Associated with High Accumulation of Tau in the Temporal Lobes"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-05-10"},"publish_date":"2019-05-10","publish_status":"0","recid":"75788","relation_version_is_last":true,"title":["Amyloid-Negative Dementia in the Elderly is Associated with High Accumulation of Tau in the Temporal Lobes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:19:56.104351+00:00"}