@article{oai:repo.qst.go.jp:00075788,
 author = {Takeuchi, Jun and Kikukawa, Takayuki and Saito, Haruna and Hasegawa, Itsuki and Takeda, Akitoshi and Hatsuta, Hiroyuki and Kawabe, Joji and Wada, Yasuhiro and Mawatari, Aya and Igesaka, Ami and Doi, Hisashi and Watanabe, Yasuyoshi and Shimada, Hitoshi and Kitamura, Soichiro and Higuchi, Makoto and Suhara, Tetsuya and Itoh, Yoshiaki and Hitoshi, Shimada and Soichiro, Kitamura and Makoto, Higuchi and Tetsuya, Suhara},
 journal = {The Open Biomedical Engineering Journal},
 month = {Mar},
 note = {Background:
We previously reported that among cases clinically diagnosed with Alzheimer’s disease, the proportion of amyloid beta (Aβ) -negative case
increases in the elderly population. Tauopathy including Argyrophilic Grain Disease (AGD) and Neurofibrillary Tangle-Predominant Dementia
(NFTPD), may be the leading causes of such dementia.
Objective:
To evaluate the involvement of tau, we studied tau accumulation in Amyloid-Negative Dementia Cases in the Elderly (ANDE) with Positron
Emission Tomography (PET).
Methods:
Seven cases with slowly progressive dementia who were older than 80 years and were negative for Aβ were studied. In one case, autopsy obtained
2 years after the PET examination revealed neurofibrillary tangles limited around the parahippocampal gyrus. Four cases showed strong laterality
in magnetic resonance imaging atrophy (clinical AGD), while the other three cases had no significant laterality in atrophy (clinical NFTPD). Agecorrected
PET data of healthy controls (HC; n = 12) were used as control. Tau accumulation was evaluated with [11C]PBB3-PET.
Results:
High accumulation was found in the lateral temporal cortex in ANDE. In autopsy case, scattered neurofibrillary tangles were found in the
parahippocampal gyrus. In addition, there was a very high accumulation of PBB3 in the large area of bilateral parietal lobes, although no
corresponding tau component was found in the autopsied case.
Conclusion:
Relatively high burden of tau deposition was commonly observed in the lateral temporal cortex and parietal cortex of ANDE, part of which may
explain dementia in these subjects. [11C]PBB3 may be useful in detecting tauopathy in ANDE.},
 pages = {55--66},
 title = {Amyloid-Negative Dementia in the Elderly is Associated with High Accumulation of Tau in the Temporal Lobes},
 volume = {13},
 year = {2019}
}