@misc{oai:repo.qst.go.jp:00075679,
 author = {山崎, 香奈 and 西井, 龍一 and 東, 達也 and 牧島, 弘和 and 粕谷, 吾朗 and 辻, 比呂志 and 吉永, 恵一郎 and 鎌田, 正 and Yamazaki, Kana and Nishii, Ryuichi and Higashi, Tatsuya and Makishima, Hirokazu and Kasuya, Goro and Tsuji, Hiroshi and Yoshinaga, Keiichiro and Kamada, Tadashi},
 month = {Apr},
 note = {[Objective] 
Choroidal melanoma is the most common primary ocular malignant tumor. I-123 IMP SPECT imaging was reported to be useful diagnostic imaging tool, however the diagnostic values in terms of assessment of fused image with CT/MRI and the semi-quantitative evaluation of the IMP-SPECT are still left to be discussed.

[Materials and Methods] 
Among patients who visited our institution for carbon-ion radiotherapy, ten patients who received I-123 IMP SPECT imaging were enrolled in this investigation. Fifteen min and 24 hours after intravenous injection of the radiotracer, SPECT imaging was performed using a gamma camera (E.CAM, Canon Medical, Tokyo, Japan). All acquired SPECT images were fused with CT or MRI images using a fusion viewer software (AZE-Hayabusa, AZE, Japan). ROIs of the tumor, contralateral normal choroidal tissue and normal soft tissue referring to CT or MRI image were analyzed, followed by semi-quantitative evaluation was assessed using non-parametric Wilcoxon rank sum test.

[Results]
All tumors were visualized clearly in the 24h-SPECT image than those in 15min-SPECT image. The uptake index (UI) of the tumor: (tumor count) / (normal soft tissue count) and the contralateral normal choroidal tissue: (normal choroidal tissue count) / (normal soft tissue count) were 3.16+/-0.97 and 1.35+/-0.17, respectively (p < 0.001). The tumor-to-normal tissue ratios was 7.78+/-5.10.

[Conclusion]
I-123 IMP SPECT imaging performed 24h after injection of the radiotracer and fusion-image-analysis with CT or MRI were useful for detection of the choroidal melanoma. Also semi-quantitative evaluation using the fused images using tumor-UI and T/N ratio were considered to be valuable imaging techniques for diagnosis of the choroidal melanoma., 第78回日本医学放射線学会総会},
 title = {Assessment of SPECT-CT fusion images and semi-quantitative evaluation of I-123 IMP SPECT in patients with ocular choroidal melanoma.},
 year = {2019}
}