{"created":"2023-05-15T14:55:39.648544+00:00","id":75572,"links":{},"metadata":{"_buckets":{"deposit":"bcff24da-a141-41f1-b307-975054e18721"},"_deposit":{"created_by":1,"id":"75572","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"75572"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00075572","sets":["10:28"]},"author_link":["909069","909074","909073","909067","909066","909076","909070","909072","909068","909075","909071","909065"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-04-02","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The astatine-211 (At-211) labeled compound, 4-[211At]astato-L-phenylalanine, is one of the most promising amino acid derivatives for use in targeted alpha therapy (TAT) for various cancers. Electrophilic demetallation of stannyl precursor is the most widely used approach for labeling biomolecules with At-211. However, the low acid-resistance of the stannyl precursor necessitates the use of a N- and C- terminus protected precursor, which causes low overall radiochemical yield (RCY) due to the multiple synthetic steps involved. A deprotected organosilyl compound, 4-triethylsilylphenylalanine, was employed for direct synthesis of the astatinated phenylalanine in this study. ","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"11th International Symposium on Targeted-Alpha-Therapy (TAT11)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"909065","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mohammad, Anwar-Ul Azim"}],"nameIdentifiers":[{"nameIdentifier":"909066","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishinaka, Ichiro"}],"nameIdentifiers":[{"nameIdentifier":"909067","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Ichiro"}],"nameIdentifiers":[{"nameIdentifier":"909068","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oshima, Yasuhiro"}],"nameIdentifiers":[{"nameIdentifier":"909069","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"909070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishioka, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"909071","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Shigeki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"909072","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishinaka, Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"909073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"909074","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oshima, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"909075","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishioka, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"909076","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Synthesis of 4-[211At]astato-L-phenylalanine via electrophilic demetallation from a silyl precursor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis of 4-[211At]astato-L-phenylalanine via electrophilic demetallation from a silyl precursor"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-13"},"publish_date":"2019-03-13","publish_status":"0","recid":"75572","relation_version_is_last":true,"title":["Synthesis of 4-[211At]astato-L-phenylalanine via electrophilic demetallation from a silyl precursor"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:06:10.906486+00:00"}