{"created":"2023-05-15T14:55:36.553299+00:00","id":75493,"links":{},"metadata":{"_buckets":{"deposit":"b5bba6e1-17a0-4d38-88e6-363868224d20"},"_deposit":{"created_by":1,"id":"75493","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"75493"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00075493","sets":["1"]},"author_link":["894390","894392","894398","894389","894394","894396","894397","894395","894393","894391"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"301","bibliographicPageStart":"294","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"Biotechnology & Biotechnological Equipment "}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We used a mitochondria-penetrating nitroxide, mito-TEMPO, as a contrast probe for imaging of kidney dysfunction in mice, based on the redox-imbalance and oxidative stress in the renal tissues. Kidney dysfunction was triggered by hypercholesterolemia. The mice were divided in three groups: (i) on normal diet (ND; control); (ii) on cholesterol diet (CD); (iii) on cholesterol plus cholestyramine diet (CC). CD mice showed increased plasma levels of total cholesterol and non-HDL-cholesterol, as well as increased serum levels of blood urea nitrogen, uric acid and creatinine, compared to ND mice. CC mice showed slightly increased plasma levels of total cholesterol and HDL-cholesterol, but not non-HDL-cholesterol, compared to ND mice. The serum levels of blood urea nitrogen, uric acid and creatinine in CC mice were equal to those in ND mice. The MRI signal of mito-TEMPO in the kidneys was characterized by: high intensity and long life-time in CD mice, indicating a high oxidative capacity of renal tissues; poor intensity and short life-time in ND mice, indicating a high reducing capacity of renal tissues; moderate intensity and relatively short life-time in CC mice, which shows the protective effect of lipid-lowering agents against oxidative damage. The data suggest that hypercholesterolemia induces redox-imbalance and oxidative stress in kidneys and this process could be visualized using MRI and mito-TEMPO as a redox-sensitive contrast substance.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1080/13102818.2019.1573153","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.tandfonline.com/doi/full/10.1080/13102818.2019.1573153","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1310-2818","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Lazarova, Dessislava"}],"nameIdentifiers":[{"nameIdentifier":"894389","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Sayaka"}],"nameIdentifiers":[{"nameIdentifier":"894390","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii , Itsuko"}],"nameIdentifiers":[{"nameIdentifier":"894391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zlateva , Genoveva"}],"nameIdentifiers":[{"nameIdentifier":"894392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhelev , Zhivko"}],"nameIdentifiers":[{"nameIdentifier":"894393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"894394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova, Rumiana"}],"nameIdentifiers":[{"nameIdentifier":"894395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Sayaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"894396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"894397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova, Rumiana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"894398","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Imaging of redox-imbalance and oxidative stress in kidney in vivo, induced by dietary cholesterol","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Imaging of redox-imbalance and oxidative stress in kidney in vivo, induced by dietary cholesterol"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-27"},"publish_date":"2019-03-27","publish_status":"0","recid":"75493","relation_version_is_last":true,"title":["Imaging of redox-imbalance and oxidative stress in kidney in vivo, induced by dietary cholesterol"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:25:03.262845+00:00"}