{"created":"2023-05-15T14:55:18.858151+00:00","id":75179,"links":{},"metadata":{"_buckets":{"deposit":"8137362c-1c91-44f7-84dd-acd2105a53ff"},"_deposit":{"created_by":1,"id":"75179","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"75179"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00075179","sets":["10:28"]},"author_link":["742159","742162","742154","742163","742161","742164","742160","742155","742158","742157","742165","742156"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2019-04-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Flavonols show an efficient scavenging activity against reactive oxygen radicals.  However, the detailed mechanism has yet to be fully clarified.  There are two mechanism for the radical-scavenging reactions of phenolic antioxidants, i.e., one-step hydrogen-atom transfer (HAT) and electron transfer followed by proton transfer (ET-PT).  In this study, we discuss the radical-scavenging mechanism for 6 flavonols, which are myricetin (Myr), quercetin (Que), kaempferol (Kae), and 3 methylated quercetin analogs (2’-MeQue, 5’-MeQue, and Me2Que), based on the relationships between the scavenging rate constants (k) against galvinoxyl radical and thermodynamic parameters, such as O-H bond dissociation energies (DHT) and ionization potentials (IP), calculated by the density functional theory (DFT).\nThe k values were determined in deaerated acetonitrile at 298 K by a stopped-flow technique.  DFT calculations were carried out at the B3LYP/6-31G(d) level.\nThe k value increases in the order: Que < 2’-MeQue ≈ Kae < Me2Que < Myr < 5’-MeQue.  The plot of the logarithm of the k values (log k) vs. DHT or IP values revealed that the log k values for 5’-MeQue, Myr, Me2Que, and Que are linearly correlated with their IP values.  These results suggest that the radical-scavenging reaction by these 4 flavonols may proceeds via the ET-PT mechanism.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 9th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia)","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakanishi, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"742154","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Kei"}],"nameIdentifiers":[{"nameIdentifier":"742155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Kohei"}],"nameIdentifiers":[{"nameIdentifier":"742156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ken-ichiro, Matsumoto"}],"nameIdentifiers":[{"nameIdentifier":"742157","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ozawa, Toshihiko"}],"nameIdentifiers":[{"nameIdentifier":"742158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hamada, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"742159","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukuhara, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"742160","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi, Ikuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"742161","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Kei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"742162","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Kohei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"742163","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Kenichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"742164","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ozawa, Toshihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"742165","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Structure-Activity and Structure-Mechanism Relationships for the Radical-Scavenging Reaction of Flavonols","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Structure-Activity and Structure-Mechanism Relationships for the Radical-Scavenging Reaction of Flavonols"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-15"},"publish_date":"2019-03-15","publish_status":"0","recid":"75179","relation_version_is_last":true,"title":["Structure-Activity and Structure-Mechanism Relationships for the Radical-Scavenging Reaction of Flavonols"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T01:49:14.476898+00:00"}