@misc{oai:repo.qst.go.jp:00075088,
 author = {Wang, Bing and Liu, Cuihua and Tanaka, Kaoru and Katsube, Takanori and Hirokazu, Hirakawa(発表者) and Ninomiya, Yasuharu and Maruyama, Kouichi and Murakami, Masahiro and Fujita, Kazuko and Liu, Qiang and Fujimori, Akira and Nenoi, Mitsuru and Wang, Bing and Liu, Cuihua and Tanaka, Kaoru and Katsube, Takanori and Hirakawa, Hirokazu and Ninomiya, Yasuharu and Maruyama, Kouichi and Murakami, Masahiro and Fujita, Kazuko and Fujimori, Akira and Nenoi, Mitsuru},
 month = {Mar},
 note = {Existence of radioadaptive response (RAR) was reported in varied biosystems. RAR is capable of reducing genotoxicity, cell transformation, mutation and carcinogenesis but the underlying mechanisms remain fragmented. The first RAR mouse model called “Yonezawa Effect” was established by Yonezawa and colleagues using low LET X-rays as both the priming and the challenge doses, and rescue of bone marrow death as the endpoint. In a series of investigations, we further demonstrated that existence of RAR using different types of ionizing radiation (IR) including high LET heavy ions; increase in the hematopoietic stem cells/hematopoietic progenitor cells (HSCs/HPCs) measured as endogenous colony forming units-spleen under RAR; and reduction of delayed homologous recombination (HR) in the nucleated cells in hematopoietic tissues (bone marrow and spleen). These findings suggest that RAR in mice induced by different types of IR would share a common underlying mechanism: the priming IR-induced resistance in the blood forming tissues, leading to a protective effect on the HSCs/HPCs and rescuing the animals from bone marrow death. On the other hand, reduction of delayed HR may be at least a part of the mechanisms underlying decreased carcinogenesis by RAR. These findings provide a new insight into the mechanistic study on RAR in vivo and suggest that application of RAR would contribute to a more rigorous and scientifically-grounded system of radiation protection., 新領域学術研究「宇宙に生きる」2018年度第2回全体会議},
 title = {Induction of Radioadaptive Response in Mice - Characterization of Radioadaptive Response in a Mouse Model (Yonezawa Effect)},
 year = {2019}
}