@article{oai:repo.qst.go.jp:00075036,
 author = {Liu, Cuihua and Hirakawa, Hirokazu and Tanaka, Kaoru and Mohd Saaya, Fazliana and Nenoi, Mitsuru and Fujimori, Akira and Wang, Bing and Liu, Cuihua and Hirakawa, Hirokazu and Tanaka, Kaoru and Mohd saaya, Fazliana and Nenoi, Mitsuru and Fujimori, Akira and Wang, Bing},
 issue = {1},
 journal = {Dose Response},
 month = {Mar},
 note = {Radiotherapy (RT) treats cancer effectively with high doses of ionizing radiation (IR) to kill cancer cells and shrink tumors while bearing the risk of developing different side effects including secondary cancer, which is of the most concern for long-term health consequences. Genomic instability (GI) is a characteristic of most cancer cells, and IR-induced GI can manifest as delayed homologous recombination (HR). Radioadaptive response (RAR) is capable of reducing genotoxicity, cell transformation, mutation and carcinogenesis but the rational evidence describing its contributions to the reduction of radiation risk, in particular, carcinogenesis, remains fragmented. In this work, to investigate the impact of RAR on high dose IR-induced GI measured as delayed HR, the frequency of recombinant cells was comparatively studied under RAR-inducible and -uninducible conditions in the nucleated cells in hematopoietic tissues (bone marrow and spleen) using the Rosa26 Direct Repeat-GFP homozygote mice. Results demonstrated that the frequency of recombinant cells was significantly lower in hematopoietic tissues under RAR-inducible condition. These findings suggest that reduction of delayed HR may be at least a part of the mechanisms underlying decreased carcinogenesis by RAR, and application of RAR would contribute to a more rigorous and scientifically-grounded system of radiation protection in RT.
キーワード：Adaptive response, ionizing radiation, genomic instability, homologous recombination, rosa26 direct repeat-GFP (RaDR-GFP) mice},
 title = {Reduction of Delayed Homologous Recombination by Induction of Radioadaptive Response in RaDR-GFP Mice (Yonezawa Effect): An Old Player with A New Role},
 volume = {17},
 year = {2019}
}