@misc{oai:repo.qst.go.jp:00074920,
 author = {赤羽, 恵一 and Akahane, Keiichi},
 month = {Nov},
 note = {Purpose: In radionuclide therapy, beta and alpha particle emitters have been used as weakly penetrating radiation sources. However, the conventional dose calculation method for photons would not always be suitable for radionuclide therapy due to the short range in the body. The purpose of this study is to make a model of dose estimations for weakly penetrating radiation in radionuclide radiotherapy.

Methods: The issues of dose estimations to be considered in radionuclide therapy are the heterogeneously distributed doses and the higher dose levels for the possibility of not only stochastic but also deterministic effects. The former depends on the local concentrations of radionuclide with high radioactivity, and the latter is related to the physical and protection quantities with respect to radiation and tissue weighting factors. The dose distributions are determined based on the diagnostic images, and the exposed volumes are considered in each dose levels.

Results: The absorbed fractions from the source to target organs can be calculated considering the volumes as the sources in which the radionuclide concentrated. The wide range dose gradient in one organ requires the reconsideration of the concept of averaged absorbed dose, radiation and tissue weighting factors. The model estimates the internal doses in radionuclide therapy considering both stochastic and deterministic effects. This method can be applied for other radiotherapy and interventional radiology., The 18th Asia-Oceania Congress of Medical Physics (AOCMP) and the 16th South-East Asia Congress of Medical Physics (SEACOMP)},
 title = {Dose Estimation Model for Weakly Penetrating Radiation in Radionuclide Radiotherapy},
 year = {2018}
}