@article{oai:repo.qst.go.jp:00074856,
 author = {Emily, Debrot and Bolst, David and James, Benjamin and Linh Tran, Thuy and Guatelli, Susanna and Petasecca, Marco and A Prokopovich , Dale and Reinhard, Mark and 松藤, 成弘 and Jackson, Michael and Lerch, Michael and B Rosenfeld, Anatoly and Debrot, Emily and BOLST, David and James, Benjamin and Linh Tran, Thuy and Petasecca, Marco and Prokopovich, Dale and Matsufuji, Naruhiro and Lerch, Michael and Anatoly, Rozenfeld},
 issue = {1-2},
 journal = {Radiation Protection dosimetry},
 month = {Mar},
 note = {An experimental and simulation-based study was performed on a 12C ion minibeam radiation therapy (MBRT) field produced with a clinical broad beam and a brass multi-slit collimator (MSC). Silicon-on-insulator (SOI) microdosimeters developed at the Centre for Medical Radiation Physics (CMRP) with micron sized sensitive volumes were used to measure the microdosimetric spectra at varying positions throughout the MBRT field and the corresponding dose-mean lineal energies and RBE for 10% cell survival (RBE10) were calculated using the modified Microdosimetric Kinetic Model (MKM). An increase in the average RBE10 of ∼30% and 10% was observed in the plateau region compared to broad beam for experimental and simulation values, respectively. The experimental collimator misalignment was determined to be 0.7° by comparison between measured and simulated microdosimetric spectra at varying collimator angles. The simulated dose-mean lineal energies in the valley region between minibeams were found to be higher on average than in the minibeams due to higher LET particles being produced in these regions from the MSC. This work presents the first experimental microdosimetry measurements and characterisation of the local biological effectiveness in a MBRT field.},
 pages = {160--166},
 title = {INVESTIGATING VARIABLE RBE IN A 12C MINIBEAM FIELD WITH MICRODOSIMETRY AND GEANT4},
 volume = {183},
 year = {2019}
}