@misc{oai:repo.qst.go.jp:00074787,
 author = {Nishii, Ryuichi and Saga, Tsuneo and Sudo, Hitomi and Yoshinaga, Keiichiro and Higashi, Tatsuya and Nishii, Ryuichi and Saga, Tsuneo and Sudo, Hitomi and Yoshinaga, Keiichiro and Higashi, Tatsuya},
 month = {Apr},
 note = {Objective: A novel radiopharmaceutical, 4’-[methyl-11C]-thiothymidine (4DST), has been developed as an in vivo cell proliferation marker based on the DNA incorporation method. The purpose of this study was to evaluate 4DST uptake in patients with lung tumor and to correlate the results with proliferative activity and tumor grade, in comparison with 18F-FDG (FDG).
Methods: Investigations of 4DST and FDG PET/CT were performed retrospectively in 23 lesions of 22 patients with lung tumor (18 male and 4 femal, mean age; 67.4+/- 8.6 y.o., median; 69 y.o.). The maximum standardized uptake value (SUVmax) for tumor were calculated. Histopathological diagnosis was proven by surgery when the clinical diagnosis was malignancy. Others were diagnosed as benign lung nodule by clinically follow-up. Proliferative activity as indicated by the Ki-67 index was estimated in tissue specimens.
Results: Of 23 lung tumors examined, 19 lesions were malignant tumor (SqCC; 5, Adenoca.; 14), other 4 lesion were benign after surgery or clinical course observation. In 4DST PET/CT study, SUVmax were 3.04 in malignant lesion (2.89 for SqCC, 3.10 for Adenoca.) and 1.87 in benign lesion, respectively (P<0.05). In FDG PET/CT study, SUVmax were 5.62 in malignant lesion (7.46 for SqCC, 4.96 for Adenoca.) and 4.48 in benign lesion, respectively (n.s.). Linear regression analysis between 4DST and FDG indicated a correlation for SUVmax (R2 = 0.30, P<0.01). The Expression of Ki-67 of SqCC was 32.4 +/- 7.44 and that of Adeno ca. was 24.64 +/- 29.84, respectively (n.s.). Linear regression analysis indicated a correlation between FDG and Ki-67 index of or SUVmax (R2 = 0.50, P<0.005), however a significant correlation between FDG and Ki-67 index was not found in this population of this study. In several case of adenocarcinoma, mixed subtype, were relatively low Ki-67 index while the SUVmax of 4DST were high.
Conclusion: 4DST PET/CT is feasible for imaging of lung tumors, as well as FDG PET/CT., 世界核医学会(WFNMB2018)},
 title = {Assessment of 4DST uptake and Ki-67 index in patients with lung tumor in comparison with FDG uptake.},
 year = {2018}
}