{"created":"2023-05-15T14:55:00.132761+00:00","id":74752,"links":{},"metadata":{"_buckets":{"deposit":"8c49cdf1-0799-4f94-8820-1ed011d3501a"},"_deposit":{"created_by":1,"id":"74752","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"74752"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00074752","sets":["1"]},"author_link":["873275","873273","873276","873271","873272","873282","873270","873280","873274","873277","873278","873279","873281"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"356","bibliographicPageStart":"343","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Journal of Cell Communication and Signaling"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"While the dose-response relationship of radiation-induced bystander effect (RIBE) is controversial at low and high linear energy\ntransfer (LET), mechanisms and effectors of cell-to-cell communication stay unclear and highly dependent of cell type. In the\npresent study, we investigated the capacity of chondrocytes in responding to bystander factors released by chondrosarcoma cells irradiated at different doses (0.05 to 8 Gy) with X-rays and C-ions. Following a medium transfer protocol, cell survival,\nproliferation and DNA damages were quantified in bystander chondrocytes. The bystander factors secreted by chondrosarcoma\ncells were characterized. A significant and major RIBE response was observed in chondrocyte cells (T/C-28a2) receiving conditioned medium from chondrosarcoma cells (SW1353) irradiated with 0.1 Gy of X-rays and 0.05 Gy of C-ions, resulting in cell survivals of 36% and 62%, respectively. Micronuclei induction in bystander cells was observed from the same low doses. The cell survival results obtained by clonogenic assays were confirmed using impedancemetry. The bystander activity was vanished after a heat treatment or a dilution of the conditioned media. The cytokines which are well known as bystander factors,TNF-α and IL-6, were increased as a function of doses and LET according to an ELISA multiplex analysis. Together, the results demonstrate that irradiated chondrosarcoma cells can communicate stress factors to non-irradiated chondrocytes, inducing a wide and specific bystander response related to both doses and LET.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s12079-019-00515-9","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s12079-019-00515-9","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1873-9601","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Lepleux, Charlotte"}],"nameIdentifiers":[{"nameIdentifier":"873270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aurélie, Marie-Brasset"}],"nameIdentifiers":[{"nameIdentifier":"873271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":" Mihaela Temelie"}],"nameIdentifiers":[{"nameIdentifier":"873272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Boulanger, Marion"}],"nameIdentifiers":[{"nameIdentifier":"873273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Émilie, Brotin"}],"nameIdentifiers":[{"nameIdentifier":"873274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mary B. Goldring"}],"nameIdentifiers":[{"nameIdentifier":"873275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirtz, Christophe"}],"nameIdentifiers":[{"nameIdentifier":"873276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Guillaume Varès,"}],"nameIdentifiers":[{"nameIdentifier":"873277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島, 徹夫"}],"nameIdentifiers":[{"nameIdentifier":"873278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saintigny, Yannick"}],"nameIdentifiers":[{"nameIdentifier":"873279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Diana Savu"}],"nameIdentifiers":[{"nameIdentifier":"873280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"François, Chevalier"}],"nameIdentifiers":[{"nameIdentifier":"873281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Tetsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"873282","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Bystander effectors of chondrosarcoma cells irradiated at different LET impair proliferation of chondrocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Bystander effectors of chondrosarcoma cells irradiated at different LET impair proliferation of chondrocytes"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-17"},"publish_date":"2019-03-17","publish_status":"0","recid":"74752","relation_version_is_last":true,"title":["Bystander effectors of chondrosarcoma cells irradiated at different LET impair proliferation of chondrocytes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:49:41.506645+00:00"}