@article{oai:repo.qst.go.jp:00074722,
 author = {Asamizu, Syumpei and Yanagisawa, Masaomi and Ishizuka, Takumi and 佐藤, 勝也 and 大野, 豊 and Onaka, Hiroyasu and Sato, Katsuya and Ono, Yutaka},
 journal = {QST Takasaki Annual Report 2017},
 month = {Mar},
 note = {Actinomycetes, gram-positive bacteria, have been known as  a majour source of bioactive natural product which can be drug candidates. Object of this study is to elucidate the gene(s) which are involved in the response for activation of secondary metabolism within actinomycetes. Elucidation of the mechanism can be expected to lead for creation of genetic tools to generate novel bioactive natural products. In this study, we examined a mutant library of Streptomyces coelicolor generated by carbon ion beams irradiation. As a result, mutants obtained from 100 Gy irradiation contained average 2.0 mutations (14 mutations in 7 mutants). Mutants obtained from 200 Gy irradiation contained average 3.3 mutations (30 mutations in 9 mutants).},
 title = {Analysis of Response Deficient Mutants of Streptomyces coelicolor to Contact-dependent Stimuli},
 year = {2019}
}