{"created":"2023-05-15T14:54:55.709377+00:00","id":74635,"links":{},"metadata":{"_buckets":{"deposit":"9843b192-5fd6-4aeb-8cd8-422869684197"},"_deposit":{"created_by":1,"id":"74635","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"74635"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00074635","sets":["1"]},"author_link":["746540","746542","746543","746539","746544","746548","746541","746545","746547","746546","746538"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"155-176","bibliographicVolumeNumber":"176","bibliographic_titles":[{"bibliographic_title":"British journal of pharmacology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recent findings suggest that co-expression of NOS2 and COX2 is a strong prognostic indicator in triple-negative breast cancer patients. These two key inflammation-associated enzymes are responsible for the biosynthesis of NO and PGE , respectively, and can exert their effect in both an autocrine and paracrine manner. Impairment of their physiological regulation leads to critical changes in both intra-tumoural and intercellular communication with the immune system and their adaptation to the hypoxic tumour micro-environment. Recent studies have also established a key role of NOS2-COX2 in causing metabolic shift. This review provides an extensive overview of the role of NO and PGE in shaping communication between the tumour micro-environment composed of tumour and immune cells that in turn favours tumour progression and metastasis. LINKED ARTICLES: This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"30152521","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/bph.14488","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0007-1188","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Basudhar, Debashree"}],"nameIdentifiers":[{"nameIdentifier":"746538","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bharadwaj, Gaurav"}],"nameIdentifiers":[{"nameIdentifier":"746539","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Somasundaram, Veena"}],"nameIdentifiers":[{"nameIdentifier":"746540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Y S Cheng, Robert"}],"nameIdentifiers":[{"nameIdentifier":"746541","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"A Ridnour, Lisa"}],"nameIdentifiers":[{"nameIdentifier":"746542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujita, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"746543","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"J Lockett, Stephen"}],"nameIdentifiers":[{"nameIdentifier":"746544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"K Anderson, Stephen"}],"nameIdentifiers":[{"nameIdentifier":"746545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"W McVicar, Daniel"}],"nameIdentifiers":[{"nameIdentifier":"746546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"A Wink, David"}],"nameIdentifiers":[{"nameIdentifier":"746547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujita, Mayumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"746548","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Understanding the tumour micro-environment communication network from an NOS2/COX2 perspective.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Understanding the tumour micro-environment communication network from an NOS2/COX2 perspective."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-06"},"publish_date":"2019-03-06","publish_status":"0","recid":"74635","relation_version_is_last":true,"title":["Understanding the tumour micro-environment communication network from an NOS2/COX2 perspective."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T01:14:07.952627+00:00"}