@article{oai:repo.qst.go.jp:00074635,
 author = {Basudhar, Debashree and Bharadwaj, Gaurav and Somasundaram, Veena and Y S Cheng, Robert and A Ridnour, Lisa and Fujita, Mayumi and J Lockett, Stephen and K Anderson, Stephen and W McVicar, Daniel and A Wink, David and Fujita, Mayumi},
 issue = {2},
 journal = {British journal of pharmacology},
 month = {Jan},
 note = {Recent findings suggest that co-expression of NOS2 and COX2 is a strong prognostic indicator in triple-negative breast cancer patients. These two key inflammation-associated enzymes are responsible for the biosynthesis of NO and PGE , respectively, and can exert their effect in both an autocrine and paracrine manner. Impairment of their physiological regulation leads to critical changes in both intra-tumoural and intercellular communication with the immune system and their adaptation to the hypoxic tumour micro-environment. Recent studies have also established a key role of NOS2-COX2 in causing metabolic shift. This review provides an extensive overview of the role of NO and PGE in shaping communication between the tumour micro-environment composed of tumour and immune cells that in turn favours tumour progression and metastasis. LINKED ARTICLES: This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc.},
 title = {Understanding the tumour micro-environment communication network from an NOS2/COX2 perspective.},
 volume = {176},
 year = {2019}
}