{"created":"2023-05-15T14:54:20.503351+00:00","id":73847,"links":{},"metadata":{"_buckets":{"deposit":"79492768-9bc6-409a-8cb8-97a6af3768d5"},"_deposit":{"created_by":1,"id":"73847","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"73847"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00073847","sets":["1"]},"author_link":["804171","804159","804167","804161","804172","804173","804158","804164","804165","804168","804175","804156","804162","804166","804169","804174","804157","804170","804163","804160"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{"bibliographic_title":"Contrast Media & Molecular Imaging"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introductions. [N-methyl-C-11]α-Methylaminoisobutyric acid (MeAIB) is an artificial amino acid radiotracer used for PET study, which is metabolically stable in vivo. In addition, MeAIB is transported by system A neutral amino acid transport, which is observed ubiquitously in all types of mammalian cells. It has already been shown that MeAIB-PET is useful for malignant lymphoma, head and neck cancers, and lung tumors. However, there have been no reports evaluating the usefulness of MeAIB-PET in the diagnosis of brain tumors. The purpose of this study is to investigate the efficacy of system A amino acid transport PET imaging, MeAIB-PET, in clinical brain tumor diagnosis compared to [S-methyl-C-11]-L-methionine (MET)-PET. Methods. Thirty-one consecutive patients (male: 16, female: 15), who were suspected of having brain tumors, received both MeAIB-PET and MET-PET within a 2-week interval. All patients were classified into two groups: Group A as a benign group, which included patients who were diagnosed as low-grade astrocytoma, grade II or less, or other low-grade astrocytoma (n=12) and Group B as a malignant group, which included patients who were diagnosed as anaplastic astrocytoma, glioblastoma multiforme (GBM), or recurrent GBM despite prior surgery or chemoradiotherapy (n=19). PET imaging was performed 20 min after the IV injection of MeAIB and MET, respectively. Semiquantitative analyses of MeAIB and MET uptake using SUVmax and tumor-to-contralateral normal brain tissue (T/N) ratio were evaluated to compare these PET images. ROC analyses for the diagnostic accuracy of MeAIB-PET and MET-PET were also calculated. Results. In MeAIB-PET imaging, the SUVmax was 1.20 ± 1.29 for the benign group and 2.94 ± 1.22 for the malignant group (ｐ＜0.005), and the T/N ratio was 3.77 ± 2.39 for the benign group and 16.83 ± 2.39 for the malignant group (ｐ＜0.005). In MET-PET, the SUVmax was 3.01 ± 0.94 for the benign group and 4.72 ± 1.61 for the malignant group (ｐ＜0.001), and the T/N ratio was 2.64 ± 1.40 for the benign group and 3.21 ± 1.14 for the malignant group (n.s.). For the analysis using the T/N ratio, there was a significant difference between the benign and malignant groups with MeAIB-PET with ｐ＜0.001. The result of ROC analysis using the T/N ratio indicated a better diagnosis accuracy for MeAIB-PET for brain tumors than MET-PET (ｐ＜0.001). Conclusions. MeAIB, a system A amino acid transport-specific radiolabeled agents, could provide better assessments for detecting malignant type brain tumors. In a differential diagnosis between low-grade and high-grade astrocytoma, MeAIB-PET is a useful diagnostic imaging tool, especially in evaluations using the T/N ratio. Clinical trial registration. This trial was registered with UMIN000032498.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Hindawi"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"33026674","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1155/2018/1292746. eCollection 2018.","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1155/2018/1292746","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1555-4309","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishii, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"804156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"804157","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kagawa, Shinya"}],"nameIdentifiers":[{"nameIdentifier":"804158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arimoto, Maya"}],"nameIdentifiers":[{"nameIdentifier":"804159","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kishibe, Yoshihiko"}],"nameIdentifiers":[{"nameIdentifier":"804160","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Masaaki"}],"nameIdentifiers":[{"nameIdentifier":"804161","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"804162","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saiki, Masaaki"}],"nameIdentifiers":[{"nameIdentifier":"804163","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arakawa, Yoshiki"}],"nameIdentifiers":[{"nameIdentifier":"804164","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamauchi, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"804165","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okuyama, Chio"}],"nameIdentifiers":[{"nameIdentifier":"804166","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hojo, Masato"}],"nameIdentifiers":[{"nameIdentifier":"804167","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Munemitsu, Toshihiro"}],"nameIdentifiers":[{"nameIdentifier":"804168","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sawada, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"804169","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Masato"}],"nameIdentifiers":[{"nameIdentifier":"804170","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawai, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"804171","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagamachi, Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"804172","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirai, Toshinori"}],"nameIdentifiers":[{"nameIdentifier":"804173","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishii, Ryuichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"804174","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Tatsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"804175","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Differential Diagnosis between Low-Grade and High-Grade Astrocytoma Using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Differential Diagnosis between Low-Grade and High-Grade Astrocytoma Using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-10-30"},"publish_date":"2018-10-30","publish_status":"0","recid":"73847","relation_version_is_last":true,"title":["Differential Diagnosis between Low-Grade and High-Grade Astrocytoma Using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:41:43.371972+00:00"}