@article{oai:repo.qst.go.jp:00073837, author = {Obata, Takayuki and Kershaw, Jeff and Tachibana, Yasuhiko and Miyauchi, Takayuki and Abe, Yoichiro and Shibata, Sayaka and Kawaguchi, Hiroshi and Ikoma, Yoko and Takuwa, Hiroyuki and Aoki, Ichio and Yasui, Masato and Obata, Takayuki and Kershaw, Jeffrey and Tachibana, Yasuhiko and Shibata, Sayaka and Kawaguchi, Hiroshi and Ikoma, Yoko and Takuwa, Hiroyuki and Aoki, Ichio}, issue = {1}, journal = {Scientific reports}, month = {Dec}, note = {We performed multi-b and multi-diffusion-time diffusion-weighted magnetic resonance imaging on aquaporin-4-expressing (AQ) and -non-expressing (noAQ) cells, and demonstrated a clear difference between the signals from the two cell types. The data were interpreted using a two-compartment (intra and extracellular spaces) model including inter-compartmental exchange. It was also assumed that restricted diffusion of water molecules inside the cells leads to the intracellular diffusion coefficient being inversely proportional to the diffusion-time. Estimates of the water-exchange-times obtained with this model are compared to those measured using an independent optical imaging technique (coherent anti-Stokes Raman scattering imaging, CARS). For both techniques it was found that the exchange-time estimated for the noAQ cells was significantly longer than that for the AQ cells.}, title = {Comparison of diffusion-weighted MRI and anti-Stokes Raman scattering (CARS) measurements of the inter-compartmental exchange-time of water in expression-controlled aquaporin-4 cells.}, volume = {8}, year = {2018} }