{"created":"2023-05-15T14:53:55.366118+00:00","id":73423,"links":{},"metadata":{"_buckets":{"deposit":"af49604d-d7e0-402c-84f2-57f59aa979b9"},"_deposit":{"created_by":1,"id":"73423","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"73423"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00073423","sets":["1"]},"author_link":["723240","723241","723242","723243","723235","723246","723245","723236","723238","723244","723239","723234","723237"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{"bibliographic_title":"Frontiers in Immunology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cancer treatment, today, consists of surgery, chemotherapy, radiation, and most recently immunotherapy. Combination immunotherapy-radiotherapy (CIR) has experienced a surge in public attention due to numerous clinical publications outlining the reduction or elimination of metastatic disease, following treatment with specifically ipilimumab and radiotherapy. The mechanism behind CIR, however, remains unclear, though it is hypothesized that radiation transforms the tumor into an in situ vaccine which immu- notherapy modulates into a larger immune response. To date, the majority of attention has focused on rotating out immunotherapeutics with conventional radiation; however, the unique biological and physical benefits of particle irradiation may prove superior in generation of systemic effect. Here, we review recent advances in CIR, with a particular focus on the usage of charged particles to induce or enhance response to cancerous disease.","subitem_description_type":"Abstract"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"エブナー, ダニエル"}],"nameIdentifiers":[{"nameIdentifier":"723234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｔｉｎｇａｎｅｌｌｉ, Ｗａｌｔｅｒ"}],"nameIdentifiers":[{"nameIdentifier":"723235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Alexander, Helm"}],"nameIdentifiers":[{"nameIdentifier":"723236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Alessandra, Bisio"}],"nameIdentifiers":[{"nameIdentifier":"723237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 滋"}],"nameIdentifiers":[{"nameIdentifier":"723238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 正"}],"nameIdentifiers":[{"nameIdentifier":"723239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川, 卓志"}],"nameIdentifiers":[{"nameIdentifier":"723240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Marco, Durante"}],"nameIdentifiers":[{"nameIdentifier":"723241","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"エブナー ダニエル","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"723242","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｔｉｎｇａｎｅｌｌｉ Ｗａｌｔｅｒ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"723243","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"723244","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"723245","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下川 卓志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"723246","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Immunoregulatory Potential of Particle Radiation in Cancer Therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Immunoregulatory Potential of Particle Radiation in Cancer Therapy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-19"},"publish_date":"2019-02-19","publish_status":"0","recid":"73423","relation_version_is_last":true,"title":["The Immunoregulatory Potential of Particle Radiation in Cancer Therapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:29:42.933053+00:00"}