{"created":"2023-05-15T14:53:47.393162+00:00","id":73248,"links":{},"metadata":{"_buckets":{"deposit":"cfbb29a1-5b94-4eb7-ad13-ab267cd5a43e"},"_deposit":{"created_by":1,"id":"73248","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"73248"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00073248","sets":["10:27"]},"author_link":["721767","721768"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015-09-02","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Neuroinflammation is a common pathological change characterized by activation of microglia in many neuropsychiatric and neurodegenerative disease, such as Alzheimer’s disease (AD). 18kDa translocator protein (TSPO), a mitochondrial protein highly expressed in activated glial cells, is a PET-measurable biomarker for neuroinflammation and with the aid of newly developed high-specific radioligands for TSPO and imaging technology, neuroinflammation in response to pathogenetic aggregates such as amyloid and tau, has been longitudinally captured in the living brain of model animals. Our and other research institutions have primarily detected association of neuroinflammation with several neuropsychiatric and neurodegenerative diseases. There, however, are still several concerns in clinical study using TSPO imaging to evaluate neuroinflammation, including what are suitable radioligands and seemingly incompatible result with animal models. One of reasons causing the complexity of imaging in human subject is a polymorphism of human TSPO, which greatly disturb the binding of most of current TSPO radioligands to different extents. Here, I would like talk about the current state of clinical imaging for neuroinflammation in neuropsychiatric and neurodegenerative diseases, potential problems and development of next-generation ligand.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"World Molecular Imaging Congress","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"季, 斌"}],"nameIdentifiers":[{"nameIdentifier":"721767","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"季 斌","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"721768","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Current State of Clinical Imaging for Neuroinflammation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Current State of Clinical Imaging for Neuroinflammation"}]},"item_type_id":"10005","owner":"1","path":["27"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-09"},"publish_date":"2015-09-09","publish_status":"0","recid":"73248","relation_version_is_last":true,"title":["Current State of Clinical Imaging for Neuroinflammation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:31:25.915910+00:00"}